坤怡宁对雌性去卵巢大鼠生殖内分泌-免疫的影响

目的：探讨坤怡宁颗粒治疗妇女更年期综合征的内在机制。方法：以去卵巢大鼠为模型,观察坤怡宁颗粒对去卵巢大鼠体重和子宫、胸腺、肾上腺等脏器系数的影响；用放免试剂盒检测血清雌二醇（E₂）,促卵泡激素（FSH）,黄体生成素（LH）,泌乳素（PRL）,白细胞介素-2（IL-2）,骨钙素（BGP）的含量。结果：坤怡宁能增加去卵巢大鼠子宫和肾上腺系数,提高其降低的E₂,IL-2和BGP,显著降低去卵巢大鼠升高的FSH,LH和PRL。结论：坤怡宁对去卵巢大鼠神经内分泌-免疫紊乱有较好的调节作用。

Effect of Kunyining capsule on reproductive ednocrine-immune

To study the therapeutic mechanism of Kunyining(KYN) on the climacteric syndrome and provide the pharmacodynamic basis. Method: Ovariectomized rats were used as model to observe the effect of KYN on weight and the index of the organ of OVX rats. The concentration of E₂, FSH, LH, PRL, BGP and IL-2 in serum were measured by competitive radio-immunological methods. Result: KYN could obviously increase the index of uterus and adrenal gland in OVX rats, and enhance the contents of E₂, IL-2 and BGP. The level of FSH, LH, PRL in serum were decreased. Conclusion: KYN can regulate beneficially the unbalanced reproductive endocrine-immune network, which is the pharmacological basis of KYN treating climacteric syndrome.