SCAD患者血清总胆红素与疾病严重程度的相关性

目的研究血清总胆红素(STB)水平与稳定型冠状动脉疾病(SCAD)严重程度之间的关系。方法纳入324例SCAD患者,根据冠状动脉病变严重程度(Syntax评分)分为低Syntax组、中Syntax组、高Syntax组;根据STB分为高STB组和低STB组。所有患者均随访36个月,比较两组STB水平、Syntax评分及MACE发生率,并进行相关性分析。结果高Syntax组STB水平低于其他组,STB水平与Syntax评分及多冠状动脉病变占比呈负相关。低STB组MACE发生率低于高STB组。STB水平能预测SCAD患者的长期预后。结论SCAD患者血清STB水平与疾病严重程度呈负相关,STB可预测SCAD严重程度和预后。

The correlation between serum total bilirubin and disease severity in patients with SCAD

The present study aimed to investigate the relationship between the serum total bilirubin level (STB) and the severity of disease in patients with stable coronary artery disease (CAD). MethodsA total of 324 SCAD patients were enrolled and divided into low Syntax group, medium Syntax group and high Syntax group according to the severity of coronary artery lesions (Syntax score). According to STB, they were divided into high STB group and low STB group according to STB level. All patients were followed up for 36 months, and the differences in STB level, Syntax score and incidence of MACE between 2 groups were compared. Spearman rank correlation, partial correlation and stepwise multiple regression were used for correlation analysis. ResultsThe STB level of the high Syntax group was lower than that of the other groups, and the STB level was negatively correlated with Syntax score and the number of diseased vessels. The incidence of MACE in low STB group was lower than that in high STB group. STB level can predict the long-term prognosis of SCAD patients. ConclusionThe STB level of SCAD patients was negatively correlated with the severity of the disease, and STB could predict the severity and prognosis of SCAD.