基于细胞色素P450酶的新型冠状病毒肺炎治疗用中药注射剂与心血管病常用化学药潜在相互作用分析

中药注射剂作为中药科技化创新制剂,在新型冠状病毒肺炎(corona virus disease 2019,COVID-19)重症患者救治中发挥着独特优势.流行病学研究发现相当数量的COVID-19重症患者合并有高血压、冠心病等心血管疾病,在治疗的同时需进行基础疾病的控制,导致中药注射剂和西药联用的药物相互作用问题日益突...

Potential drug interactions of traditional Chinese medicine injections in treatment of COVID-19 and western medicine commonly used for cardiovascular diseases base on cytochrome P450 enzyme

Traditional Chinese medicine injection, a scientific and technological innovation of traditional Chinese medicine, plays a unique advantage in the treatment of severe patients with new corona virus pneumonia (COVID-19). Epidemiological studies have found that a considerable number of severe patients with COVID-19 have cardiovascular diseases such as hypertension and coronary heart disease, which need to be controlled during anti-virus treatment, resulting in the increasingly prevalence of drug interactions between traditional Chinese medicine injections and chemical medicines. By consulting the literatures, we summarized the effects of eight commonly used traditional Chinese medicine injections in Diagnosis and Treatment Protocol for COVID-19 (Trial Version 8) on cytochrome P450 enzyme (CYP450), and analyzed their interaction with commonly used chemical medicines for cardiovascular diseases, so as to provide references for clinical rational administration and promote the advantages of traditional Chinese medicine against the epidemic disease.