中药缓控释制剂的研究进展

我国中医药发展历史悠久,很早便有了缓控释技术的雏形。现代缓控释制剂作为第3代药物制剂,具有服药周期短、药物作用时间长、安全性高、疗效好等显著的优势,已成为中药制剂领域的研究热点。中药缓控释制剂以缓释片、缓释胶囊、微囊微球及凝胶剂等剂型研究较多,结合相关文献对现代缓控释制剂的研究概况、缓控释技术在中药领域的应用及其价值和局限性进行综述,以期为中药缓控释制剂的开发提供参考。

Research progress on sustained and controlled-release preparation of traditional Chinese medicine

Traditional Chinese medicine (TCM) has a long history in China, and has existed the embryonic form of sustained and controlled release technology for a long time. As the third generation of pharmaceutical preparations, modern sustained and controlled release preparations have obvious advantages such as short drug cycle, long drug action time, high safety and good efficacy, etc. Modern sustained and controlled release preparations have become the research hotspot in the field of TCM preparations. There are many studies on formulations of TCM sustained-release tablets, sustained-release capsules, microspheres and gels. In this paper, research progress on modern sustained and controlled release preparation, the application of sustained and controlled-release technology in the field of TCM, as well as its value and limitations are reviewed, aiming to provide reference for the development of sustained and controlled release preparations of TCM.