高分辨磁共振评价年龄对动脉粥样硬化性大脑中动脉狭窄血管重构和斑块负荷的作用

目的 分析高分辨磁共振（HRMRI）评价年龄对动脉粥样硬化病大脑中动脉狭窄血管重构和斑块负荷的作用。方法 选择2018年5月至2019年12月在茂名市人民医院进行治疗的200例大脑中动脉粥样硬化患者作为研究对象，依据年龄大小，将其分为中青年组（年龄<60岁）与老年组（年龄≥ 60岁），每组100例。两组患者均实施HRMRI检查，并在HRMRI T1加权成像轴位图像中测量大脑中动脉最狭窄部位、参考部位血管面积和管腔面积，同时计算两组患者大脑中动脉狭窄程度、斑块负荷百分比、偏心指数以及阴性重构情况。结果 老年组患者斑块负荷百分比为（41.00±13.00）%，高于中青年组，阴性重构率为14.00%，低于中青年组，差异均有统计学意义（P<0.05）。Pearson相关性分析结果显示，年龄与患者斑块负荷百分比呈正相关（r=0.581，P=0.013）。结论 动脉硬化患者大脑中动脉斑块负荷及重构方式与年龄有一定关联，通过HRMRI技术能够较好地进行评价。

Effect of age on vascular remodeling and plaque load in atherosclerotic middle cerebral artery stenosis based on HRMRI

Objective To analyze the function of age on the remodeling of middle cerebral artery stenosis and plaque load based on high resolution magnetic resonance(HRMRI).Methods Two hundred patients treated with atherosclerosis in brain in Maoming People''s Hospital were selected as the study samples,and the treatment time was from May 2018 to December 2019.According to their age, they were divided into young and middle-aged group(less than 60 years old) and elderly group(more than or equal to 60 years old),with 100 patients in each group. HRMRI was performed in each group of patients, and the area of the narrowest part of the middle cerebral artery, the vascular area of the reference part and the lumen area were measured in the axial image of high-resolution T1 weighted MRI. Meanwhile, the degree of stenosis of the middle cerebral artery, the percentage of plaque load, the eccentric index and the negative reconstruction of each group of patients were calculated. Results The percentage of plaque load of the elderly group was(41.00±13.00)%, which was higher than that of young and middle-aged group, and the negative remodeling rate was 14.00%, which was lower than that of the young and middle-aged group, and the differences were statistically significant(P<0.05).The correlation of Pearson analysis showed that age was positively correlated with the percentage of plaque load (r=0.581, P=0.013).Conclusions Arteriosclerosis patients with middle cerebral artery plaque load and remodeling have a certain relationship with age, which can be better evaluated through HRMRI technology.