九味芩香含漱液治疗正畸矫治牙龈炎的临床研究

目的探讨九味芩香含漱液治疗正畸矫治牙龈炎的临床疗效。方法选取2016年9月—2020年8月在郑州市第二人民医院接受固定正畸矫治的90例牙龈炎患者,随机分为对照组(42例)和治疗组(48例)。对照组患者在3餐后、睡前以10 mL生理盐水含漱5~10 min,含漱后30 min内禁食禁水;治疗组3餐后和睡前含漱九味芩香含漱液,20 mL/次,5~10 min/次。两组均连续治疗3个月。观察两组患者临床疗效,比较治疗前后两组患者牙周指标牙龈指数(GI)、龈沟出血指数(SBI)、菌斑指数(PLI)值,龈沟液炎症因子肿瘤坏死因子-α(TNF-α)和前列腺素E2(PGE2)水平。结果治疗后,治疗组总有效率为93.75%,明显高于对照组的73.81%(P<0.001)。治疗后,两组患者GI、SBI、PLI值均显著降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,两组TNF-α、PGE2水平均较治疗前显著降低(P<0.05),且治疗组明显低于对照组(P<0.05)。结论九味芩香含漱液可改善正畸矫治牙龈炎患者牙周指标,减轻牙周组织炎症反应,具有一定的临床推广应用价值。

Clinical study on Jiuwei Qinxiang Gargle in treatment of orthodontic correction of gingivitis

Objective To explore the clinical efficacy of Jiuwei Qinxiang Gargle in treatment of orthodontic correction of gingivitis.Methods Patients(90 cases)with gingivitis in Zhengzhou Second Hospital from September 2016 to August 2020 were randomly divided into control(42 cases)and treatment(48 cases)groups.Patients in the control group gargled with 10 mL normal saline for 5—10 min after three meals and before bed,no food and water within 30 min after gargling.Patients in the treatment group were administered with Jiuwei Qinxiang Gargle,20 mL/time,5—10 min/times.Patients in two groups were treated for 3 months.After treatment,the clinical efficacy was evaluated,and the periodontal indexes of GI,SBI,and PLI value,the inflammatory factors of TNF-αand PGE2 in gingival crevicular fluid in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 93.75%,which was significantly higher than 73.81%in the control group(P<0.001).After treatment,the values of GI,SBI,and PLI in two groups were significantly decreased(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the levels of TNF-αand PGE2 in two groups were significantly lower than those before treatment(P<0.05),and these in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Jiuwei Qinxiang Gargle can improve the periodontal index of patients with gingivitis,reduce the inflammatory reaction of periodontal tissue,which has a certain clinical application value.