中药治疗缺血性脑卒中致多器官损伤的研究进展

缺血性脑卒中(cerebral ischemic stroke,CIS)可引发包括心、肝、脾、肺、肾在内的多个器官损伤,该类疾病是由多个病理环节组成,具有复杂的发病机制及高发病率、高致残率和高死亡率的特点,严重者可形成多器官功能障碍综合征(multiple organ dysfunction syndromes,MODS)。目前任何针对单一环节、单一靶点的治疗都不足以应对这一问题。研究发现中药可经多途径、多靶点,参与疾病的多个环节干预疾病。中药通过抗氧化作用、抑制炎症反应、调节能量代谢等对CIS引发的多器官损伤具有明显的保护作用。对中药及其有效成分对CIS后引起的多器官损伤及其相关机制进行了综述,以期更大程度地发挥祖国医学的治疗作用和治疗范围,为中药临床干预脑血管类合并多器官损伤类疾病提供科学依据和参考。

Research progress on traditional Chinese medicine in treatment of multiple organs injury caused by cerebral ischemic stroke

Cerebral ischemic stroke (CIS) can cause multiple organ injuries, which includes the heart, liver, spleen, lung, and kidney injuries. These diseases are composed of multiple pathological links, which have complex pathogenesis, high incidence rate, high disability rate, and high mortality rate. Severe cases can develop the multiple organ dysfunction syndromes (MODS). At present, any treatment aiming at single link and single target is not adequate to cure the disease. While it has been found that traditional Chinese medicine can intervene in many aspects of the diseases through multiple targets. Traditional Chinese medicine has obvious protective effect on MODS caused by CIS through antioxidant effect, inhibition of inflammatory reaction and regulation of energy metabolism. However, there are few related reviews. Therefore, the effects of traditional Chinese medicine and its active ingredients on multiple organ injuries after CIS are reviewed in this paper, so as to give full play to the therapeutic effect and treatment scope of traditional Chinese medicine, to provide scientific basis and reference for clinical intervention of traditional Chinese medicine in cerebrovascular diseases with multiple organ injuries.