脉络宁注射液联合硫酸镁治疗妊娠高血压综合征的临床研究

目的 探讨脉络宁注射液联合硫酸镁注射液治疗妊娠高血压综合征的临床疗效.方法 选择2018年11月—2020年10月在郑州市妇幼保健院西区就诊的84例妊娠高血压综合征患者,按照随机数字表法将84例患者分为对照组和治疗组,每组各42例.对照组给予硫酸镁注射液,首次剂量10 mL硫酸镁注射液使用5％葡萄糖液稀释至20 mL在...

Clinical study on Mailuoning Injection combined with magnesium sulfate in treatment of pregnancy-induced hypertension syndrome

Objective To investigate the clinical effect of Mailuoning Injection combined with Magnesium Sulfate Injection in treatment of pregnancy-induced hypertension syndrome.Methods Patients(84 cases)with pregnancy-induced hypertension syndrome in West District of Women&Infants Hospital of Zhengzhou from November 2018 to October 2020 were randomly divided into control and treatment groups,and each group had 42 cases.Patients in the control group were given Magnesium Sulfate Injection,the first dose of 10 mL magnesium sulfate injection was diluted to 20 mL with 5%glucose solution,and injected intravenously within 5 min,then 60 mL magnesium sulfate injection was given and diluted to 500 mL with 5%glucose solution,the injection was given intravenously at 1—2 g/h,once daily.Patients in the treatment group were po administered with Mailuoning Injection on the basis of the control group,10 mL added into 5%glucose solution 500 mL,once daily.Patients in two groups were treated for 7 d.After treatment,the clinical efficacies were evaluated,the changes of blood pressure of two groups were compared,and the serum levels of IL-18,D-dimer,and Hcy were detected before and after treatment.The adverse pregnancy outcomes of two groups were followed up.Results After treatment,the total effective rate of the treatment group was 90.48%,the control group was 73.81%,and the difference was statistically significant(P<0.05).After treatment,the systolic pressure and diastolic pressure of two groups were significantly decreased(P<0.05).And the blood pressure of the treatment group was more significantly lower than that of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of IL-18,D-dimer,and Hcy in two groups were significantly decreased(P<0.05).After treatment,the levels of IL-18,D-dimer,and Hcy in the treatment group were lower than those in the control group,and the difference was statistically significant(P<0.05).The postpartum hemorrhage,neonatal asphyxia,placental abruption and premature birth in the treatment group were lower than those in the control group(P<0.05).Conclusion Mailuoning Injection combined with Magnesium Sulfate Injection can improve the curative effect of pregnancy-induced hypertension syndrome,control blood pressure,correct blood hypercoagulability,and help to improve pregnancy outcome.