初治肺结核患者中医证候与实验室指标相关性分析

目的探索初治肺结核患者中医证候与实验室检测指标相关性。方法采用前瞻性研究,选择173例初治肺结核病患者为研究对象,采集患者基线资料、中医四诊信息及实验室检测指标,利用多分类Logistic回归分析中医证候与实验室指标相关性。结果173例初治肺结核患者,肺阴亏虚证89例(51.45%),阴虚火旺证38例(21.97%),气阴两虚证37例(21.39%),阴阳两虚证9例(5.20%)。单因素分析发现不同证候组间年龄、核酸检测(TB-DNA)、白细胞计数(WBC)、中性粒细胞绝对计数(NEUT#)、C反应蛋白(CRP)、血清总蛋白(TP)差异有统计学意义(P<0.05),多因素分析发现年龄是影响证候的独立相关因素(P<0.05)。结论初治肺结核患者中医证候以肺阴亏虚证为主,实验室检测指标TB-DNA、WBC、NEUT#、CRP、TP可作为中医证候分型参考依据,年龄可显著影响证候分型。

Correlation Analysis between TCM Syndrome Types and Laboratory Indicators in Initial Pulmonary Tuberculosis Patients

Objective To observe the correlation between TCM syndromes types of initial pulmonary tuberculosis patients and laboratory examination indicators,thus providing objective evidence for combined diagnosis and treatment of disease identification and syndrome typing.Methods A perspective study was performed.Totally 173 pulmonary tuberculosis patients initially diagnosed were recruited.The baseline data,four diagnostic information of TCM,and laboratory examinations indicators were collected.The correlation between TCM syndromes types and laboratory indicators were analyzed using multi-class Logistic regression analysis.Results Among the 173 patients,there were 89 patients with Fei-yin deficiency syndrome(FYDS;51.45%),38 patients with yin deficiency fire excess syndrome(YDFES;21.97%),37 patients with qi-yin deficiency syndrome(QYDS;21.39%),and 9 patients with yin-yang deficiency syndrome(YYDS,5.20%).Univariate analysis revealed statistical differences in age,Mycobacterium tuberculosis nucleic acid detection(TB-DNA),leukocytes count(WBC),neutrophils absolute count(NEUT#),C-reactive protein(CRP),and total serum protein(TP)among different syndrome types(P<0.05).By multivariate analysis,it was found that age was an independent factor affecting syndrome types(P<0.05).Conclusions FYDS was the primary TCM syndrome type of initially treated pulmonary tuberculosis patients.TB-DNA,WBC,NEUT#,CRP,and TP could be used as the reference for TCM syndrome typing,and age significantly affected syndrome typing.