资生丸联合柳氮磺吡啶肠溶片治疗溃疡性结肠炎的临床研究

目的探讨资生丸联合柳氮磺吡啶肠溶片治疗溃疡性结肠炎的临床疗效。方法选择2018年3月—2020年3月河南医学高等专科学校附属医院收治的113例溃疡性结肠炎患者,根据随机分层抽样法分为对照组(56例)和治疗组(57例)。对照组口服柳氮磺吡啶肠溶片,1 g/次,3次/d。治疗组在对照组治疗的基础上口服资生丸,10丸/次,3次/d。两组均治疗4周。观察两组临床疗效,比较两组临床症状改善时间、疾病活动指数(DAI)评分、血清白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平。结果治疗后,治疗组的总有效率91.23%,比对照组的73.21%更高(P<0.05)。治疗后,治疗组治愈时间、黏液脓血便消失时间、黏膜愈合时间短于对照组(P<0.05)。治疗后,两组患者DAI评分均下降(P<0.05),且治疗组DAI评分低于对照组(P<0.05)。治疗后,两组TNF-α、IL-8、CRP水平均显著下降(P<0.05),且治疗组TNF-α、IL-8、CRP水平较对照组更低(P<0.05)。结论资生丸联合柳氮磺吡啶肠溶片治疗溃疡性结肠炎患者可改善临床症状,同时还可降低血清IL-8、TNF-α、CRP水平,具有较好的疗效。

Clinical study on Zisheng Pills combined with Sulfasalazine Enteric-coated Tablets in treatment of ulcerative colitis

Objective To investigate the clinical efficacy of Zisheng Pills combined with Sulfasalazine Enteric-coated Tablets in treatment of ulcerative colitis. Methods Patients(113 cases) with ulcerative colitis in the Affiliated Hospital of Henan Medical College from March 2018 to March 2020 were randomly divided into the control group(56 cases) and the treatment group(57 cases). Patients in the control group were po administered with Sulfasalazine Enteric-coated Tablets, 1 g/time, three times daily. Patients in the treatment group were po administered with Zisheng Pills on the basis of the control group, 10 pills/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the improvement time of clinical symptoms, the DAI scores, and the levels of IL-8, TNF-α, and CRP in two groups were compared. Results After treatment, the total effective rate of the treatment group was 91.23%, which was higher than 73.21% of the control group(P < 0.05). After treatment, the cure time, the disappearance time of mucus pus and bloody stool, and the mucosal healing time of the treatment group were shorter than those of the control group(P < 0.05). After treatment, the DAI scores of two groups were decreased(P < 0.05), and the DAI score of the treatment group was lower than that of the control group(P < 0.05). After treatment, the levels of TNF-α, IL-8, and CRP in two groups were significantly decreased(P < 0.05), and the levels of TNF-α, IL-8, and CRP in the treatment group were lower than those in the control group(P < 0.05). Conclusion Zisheng Pills combined with Sulfasalazine Enteric-coated Tablets can improve the clinical symptoms of patients with ulcerative colitis, and reduce the serum levels of IL-8, TNF-α, and CRP, which has a good curative effect.