百安洗液联合硝呋太尔制霉素治疗霉菌性阴道炎的临床研究

目的 探讨百安洗液联合硝呋太尔治疗霉菌性阴道炎的临床研究.方法 选取2018年8月—2019年8月在平煤神马医疗集团总医院妇产科就诊的128例霉菌性阴道炎患者,随机分成对照组(64例)和治疗组(64例).对照组患者外用硝呋太尔制霉素阴道软胶囊,于晚上临睡前清洗外阴后阴道给药,放入阴道后穹窿处,1粒/次,1次/d,连续外...

Clinical study on Bai'an Lotion combined with nifuratel and nysfungin in treatment of mycotic vaginitis

Objective To investigate the efficacy of Bai’an Lotion combined with nifuratel and nysfungin in treatment of mycotic vaginitis.Methods A total of 128 patients with mycotic vaginitis who were admitted to the Department of Gynecology and Obstetrics of Pingmei Shenma Medical Group General Hospital from August 2018 to August 2019 were randomly divided into control group(64 cases)and treatment group(64 cases).Patients in the control group received Nifuratel and Nysfungin Vaginal Soft Capsules which was administered in the vagina after cleaning vulva before going to bed at night,and placed in the posterior fornix of the vagina,1 grain/time,for continuous external usage for 7 d.Patients in the treatment group were given Bai’an Lotion on the basis of the control group,10 mL/time,twice daily,and diluted to 100 mL with warm water to rinse the vagina,for consecutive 7 d.The clinical efficacy of the two groups was observed,and the cure time of clinical symptoms,serum oxidative stress products and serum inflammatory factors were compared between the two groups.Results After treatment,the total effective rate of 96.88%in treatment group,which was significantly higher than that of control group(76.56%,P<0.05).After treatment,the cure time of clinical symptoms such as abnormal leucorrhea,vulva pruritus,vulva vaginal pain and mucosal congestion in the treatment group was shorter than that in the control group(P<0.05).After treatment,ET-1 and MDA were significantly decreased,but NO and SOD were significantly increased in two groups(P<0.05).After treatment,ET-1 and MDA in treatment group were lower than those in control group,while NO and SOD in treatment group were higher than those in control group(P<0.05).After treatment,the serum levels of IL-4,IL-6,CRP,and TNF-αin two groups were significantly decreased(P<0.05).After treatment,the levels of these serum inflammatory factors in treatment group were significantly lower than those in control group(P<0.05).Conclusion Bai’an Lotion combined with nifuratel and nysfungin has curative effect in treatment of mycotic vaginitis,and can significantly improve the relevant clinical symptoms and local signs,and effectively reduce oxidative stress products and inflammatory response,which is safe and effective in clinical application,and has certain clinical application value.