| 蛋氨酸限制提高内源性H2S活性延缓衰老的机制研究进展 |
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| 引用本文： | 李欣,吴海燕.蛋氨酸限制提高内源性H2S活性延缓衰老的机制研究进展[J].四川生理科学杂志,2021,43(1):144-148. |
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| 作者姓名： | 李欣 吴海燕 |
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| 作者单位： | 四川大学华西基础医学与法医学院,四川 成都 610041;四川大学华西基础医学与法医学院药理学教研室,四川 成都 610041 |
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| 基金项目： | 四川省科技计划(编号:2019YJ0094);学生大创项目(编号:C2020108688)。 |
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| 摘 要： | 蛋氨酸限制(Methionine restriction,MetR)作为饮食限制的方法之一,能够改善多种无脊椎动物、啮齿类动物及包括人类灵长类动物的衰老及其相关疾病.但MetR对衰老的具体调节作用机制尚未完全明确,目前除了与饮食限制的共有机制以外,越来越多的研究表明内源性硫化氢(Endogenous hydrogen ...
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| 关 键 词： | 蛋氨酸限制 硫化氢 转硫途径 衰老 |
Research progress on the mechanism of methionine restriction delaying ageing via increasing endogenous H2S activity |
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| Li Xin,Wu Hai-yan.Research progress on the mechanism of methionine restriction delaying ageing via increasing endogenous H2S activity[J].Sichuan Journal of Physiological Sciences,2021,43(1):144-148. |
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| Authors: | Li Xin Wu Hai-yan |
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| Institution: | (Basic Medical Sciences of 2018 Grade,West China School of Basic Medicine Sciences and Forensic Medicine,Sichuan University,Chengdu 610041,China;Department of Pharmacology,West China School of Basic Medicine Sciences and Forensic Medicine,Sichuan University,Chengdu 610041,China) |
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| Abstract: | Methionine restriction(MetR),as one of the methods of dietary restriction,can improve the aging and related diseasesof a variety of invertebrates,rodents and including human primates.However,the specific regulatory mechanism of MetR on aging has not been fully clarified.At present,in addition to the shared mechanism with dietary restriction,more and more studies have shown that endogenous hydrogen sulfide(H2S)may be the main mechanismof its effect.As a water-soluble and fat-soluble small molecule gas,hydrogen sulfide plays an important role in delaying the aging process and improving aging-related diseases.This review describes the mechanism of MetR delaying aging by increasing the activity of endogenous H2S. |
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| Keywords: | Methionine restriction Hydrogen sulfide Transsulfuration pathway Aging |
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