无痛内镜下食管胃静脉曲张治疗术对轻微肝性脑病的影响

目的 探讨无痛内镜下食管胃静脉曲张治疗术(组织胶注射+套扎或组织胶+硬化剂注射)对轻微肝性脑病(MHE)的影响.方法 采用前瞻性队列研究,将92例食管胃静脉曲张患者分为MHE组(n=44)和无肝性脑病组(对照组,n=48).采用数字连接试验(NCT)、数字符号试验(DST)评估两组患者术前、术后2 h和术后24 h M...

Effect of painless endoscopic treatment of esophageal and gastric varices on mild hepatic encephalopathy

Objective To investigate the effect of painless endoscopic liver cirrhosis esophagogastric varices treatment (tissue glue injection and ligation or tissue glue and sclerosant injection) on mild hepatic encephalopathy (MHE).Methods Using a prospective cohort study, 92 patients with esophagogastric varices were divided into MHE group (n = 44) and non-hepatic encephalopathy group (control group, n = 48). All the patients occurrence of mild hepatic encephalopathy (MHE) before surgery, 2 h after surgery, and 24 h after surgery, and the anesthesia recovery time were evaluated by number connection test (NCT) and digital symbol test (DST).Results There was no significant difference in postoperative NCT score and DST score in the MHE group compared with preoperative (P > 0.05). The NCT score and DST score of the control group after operation were also not significantly different from those before the operation (P > 0.05). In terms of anesthesia resuscitation time, the MHE group required an average of (7.2 ± 2.7) min and the control group an average of (6.9 ± 3.5) min, there was no statistically significant difference between the two groups (P > 0.05).Conclusion The use of Propofol combined with Remifentanil in endoscopic surgery for esophagogastric varices has no significant effect on MHE and does not induce overt hepatic encephalopathy (OHE). It is a safe and comfortable method, and it is worthy of clinical promotion.