腹腔镜直肠癌根治术治疗直肠癌的效果及对血清疼痛因子、miR-103、miR-21与肛肠动力学指标的影响

目的 探讨腹腔镜直肠癌根治术治疗直肠癌的效果及对血清疼痛因子、miR-103、miR-21和肛肠动力学指标的影响.方法 选取2017年9月-2019年12月该院直肠癌患者93例进行前瞻性随机对照研究,简单随机化法分为观察组(n=46)和对照组(n=47).观察组采取腹腔镜直肠癌根治术,对照组行传统开腹手术.比较两组手术...

Effect of laparoscopic radical resection of rectal cancer in treatment of rectal cancer and its impact on serum pain factors, miR-103, miR-21 and anorectal dynamics indexes

Objective To investigate the effect of laparoscopic radical resection of rectal cancer in treatment of rectal cancer and its impact on serum pain factors, miR-103, miR-21 and anorectal dynamics.Methods A prospective randomized controlled study of 93 patients with rectal cancer from September 2017 to December 2019 was performed. They were divided into observation group (n = 46) and control group (n = 47) by simple randomization method. The observation group received laparoscopic radical resection of rectal cancer, and the control group underwent traditional open surgery. The surgical conditions and the incidence rate of complications, serum pain factors [neuropeptide Y (NPY), prostaglandin E₂ (PGE₂), nerve growth factor (NGF)] before operation, 1 d, and 3 d after operation, miR-103 and miR-21 before operation, 1 week after operation and 2 weeks after operation, anorectal dynamics indexes [anal longest contraction time (ALCT), anal maximum contraction pressure (AMCP), and resting rectal pressure (RRP)] levels before operation, 4 weeks after operation, and 8 weeks after operation were compared between the two groups.Results There was no significant difference in the operation time and the number of lymph node dissection between the two groups (P > 0.05); The intraoperative blood loss in the observation group was lower than that in the control group, and the anal exhaust time, eating time, and hospitalization time were shorter than those in the control group (P < 0.05); The serum NPY, PGE₂ and NGF levels of the two groups at 1 and 3 days after operation were higher than those before the operation, but the observation group was lower than that in control group (P < 0.05). The levels of serum miR-103 and miR-21 in the two groups at 1 week and 2 weeks after the operation were lower than those before the operation, and the observation group was lower than that in control group (P < 0.05). The levels of ALCT, AMCP and RRP in the two groups were lower than those before the operation at 4 weeks and 8 weeks after the operation, but the observation group was higher than that in control group (P < 0.05).Conclusion Application of laparoscopic radical resection of rectal cancer in patients with rectal cancer can effectively reduce intraoperative blood loss, shorten postoperative recovery time, inhibit expression of pain factors, regulate serum miR-103 and miR-21 levels, and promote the recovery of anorectal dynamics in patients.