高通量血液透析治疗对尿毒症患者心功能、微炎症因子及血清磷、全段甲状旁腺激素清除的影响

目的:分析高通量血液透析治疗尿毒症的临床价值.方法:将2016年9月至2018年9月我院收治的263例尿毒症患者按治疗方式不同分为对照组(低通量血液透析,n=121)和观察组(高通量血液透析,n=142),比较两组患者治疗前与治疗3个月后心功能[左室舒张期末内径(Left ventricular end diastol...

Effect of high-flux hemodialysis treatment on cardiac function,micro-inflammatory factors,serum phosphorus and total parathyroid hormone clearance in patients with uremia

Objective:To analyze the clinical values of high flux hemodialysis in the treatment of uremia.Methods:A total of 263 patientswithuremia admitted to this hospital from September 2016 to September 2018 were divided into control group(low-flux hemodialysis,n=121)and observation group(high-flux hemodialysis,n=142)according to different treatments.The cardiac function Left ventricular end diastolic inner diameter(LVEDD),End systolic diameter of left ventricle(LVESD),left ventricle Left ventricular end diastolic volume(LVEDV),Left ventricular end systolic volume(LVESV),Left ventricular posterior wall thickness(LVPWT) Interventricular septum thickness(IVST),Left ventricular ejection fraction,LVEF),the ratio of the maximum blood flow between early and late diastole(E/A)and left ventricular mass index(Left ventricular mass index,LVMI)],Tumor necrosis factor-α(TNF-α),high sensitivity C-reactive protein(hs-CRP),serum phosphorus,Intact parathyroid hormone(iPTH),B-type brain natriuretic peptide(BNP),cardiac troponin(eTnT)levels],quality of life(evaluated by the Concise Health Check Scale(SF-36))and complications between the two groups before treatment and 3 months after treatment was compared.Results:Compared with those before treatment,the levels of LVPWT,IVST,BNP,eTnT,etc.in the two groups significantly reduced,and the declining in the observation group was more significant(P<0.05).Compared with those before treatment,LVMI decreased significantly,and LVEF increased significantly(P<0.05).Compared with those before treatment,the levels of phosphorus,iPTH,TNF-α,and hs-CRP in the two groups decreased significantly,and the decline in the above indicators in the observation group was significantly more than that in the control group(P<0.05).The SF-36 score of the control group was significantly lower than that of the observation group,and the total incidence of adverse reactions was significantly higher than that of the observation group(P<0.05).Conclusion:High-throughput hemodialysis can improve the cardiac function of patients with uremia to a certain extent,reduce the levels of phosphorus,iPTH,TNF-α,hs-CRP,is safe and reliable,and can effectively improve the quality of life of patients.