替格瑞洛治疗急性心肌梗死行经皮冠状动脉介入术后患者效果观察

目的:探究替格瑞洛片对急性心肌梗死(Acute myocardial infarction,AMI)行经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)术后患者血凝状态、心功能及细胞炎症反应的影响。方法:选取我科2018年1月至2019年6月期间收治的127例AMI行PCI术后患者,根据随机数字表法进行分组,对照组患者(n=63)给予阿司匹林100 mg?次^-1,qd,口服+氯吡格雷75 mg?次^-1,qd,口服治疗,观察组64例给予阿司匹林100 mg?次^-1,qd,口服+替格瑞洛90 mg?次^-1,bid,口服治疗,治疗3月后,比较2组患者的血小板聚集率:术前、术后24 h、术后1周;心功能:术前、术后1个月、术后3个月左心室射血分数(Left ventricular ejection fractions,LVEF)、左心室舒张末径(Left ventricular diastolic enddiameter,LVDEd)、左心室收缩末径(Left ventricular systolicend diameter,LVSEd)、左心房内径(Left atrium diameter,LAd);细胞炎症反应:术前、术后3个月血清白介素-6(Interleukin-6,IL-6)、白介素-8(Interleukin-8,IL-8)、白介素-18(Interleukin-18,IL-18)、肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)水平;3月内主要不良心脑血管事件(Major adverse cardiacand cerebrovascular events,MACCE)发生率。结果:观察组术后24 h、术后1周血小板聚集率明显低于对照组(P<0.05),术后1个月、术后3个月LVEF高于对照组(P<0.05),LVDEd、LVSEd、LAd低于对照组(P<0.05);术后3个月IL-6、IL-8、IL-18、TNF-α均低于对照组(P<0.05)。观察组MACCE发生率与对照组无明显差异(P>0.05)。结论:替格瑞洛片对AMI行PCI术后患者治疗,可提高凝血功能和心功能,降低炎症反应。

Observation of the effect of ticagrelor on patients with acute myocardial infarction undergoing percutaneous coronary intervention

Objective:To explore the effects of ticagrelor tablets on blood coagulation status,cardiac function and cellular inflammation in patients with acute myocardial infarction(AMI)undergoing percutaneous coronary intervention(PCI).Methods:A total of 127 patients with AMI after PCI in our department from January 2018 to June 2019 were selected and randomly divided into control group(n=63)and observation group(n=64),After 3 months of treatment,the platelet aggregation rate,cardiac function,left ventricular ejection fraction(LVEF),left ventricular diastolic end diameter(lvded)and left ventricular end systolic diameter(LVESD)of the two groups were compared Systolic end diameter(lvsed),left atrium diameter(LAD),cellular inflammatory response:serum interleukin-6(IL-6),interleukin-8(IL-8),interleukin-18(IL-18),tumor necrosis factorα(TNF-α)before and 3 months after operation The incidence of major adverse cardiovascular and cerebrovascular events(MACCE)in 3 months.Results:The platelet aggregation rate of the observation group was significantly lower than that of the control group at 24 h and 1 week after operation(P<0.05),LVEF was higher than that of the control group at 1 month and 3 months after operation(P<0.05),lvded,lvsed and LAD were lower than those of the control group(P<0.05),and IL-6,IL-8,IL-18 and TNF-αwere lower than those of the control group at 3 months after operation(P<0.05).There was no significant difference in the incidence of MACCE between the observation group and the control group(P>0.05).Conclusion:Ticagrelor tablets can treat AMI patients undergoing PCI,which can improve blood coagulation and heart function,and reduce inflammation.