糖尿病病人血、尿TxB_2与微量白蛋白尿的关系

本文用放射免疫方法测定６０例糖尿病病人及２３例正常人尿白蛋白排泄率，血ＴｘＢ２，尿ＴｘＢ２。结果显示３１％糖尿病病人伴微量白蛋白尿。微量白蛋白尿病人、非微量白蛋白尿病人及正常人血ＴｘＢ２三者间无显著性差异（Ｐ＞０．０５）；微量白蛋白尿病人尿ＴｘＢ２排泄率显著高于非微量白蛋白尿病人和正常人（Ｐ＜０．０５），而非微量白蛋白尿病人与正常人间无显著差别（Ｐ＞０．０５）。提示糖尿病病人伴微量白蛋白尿者肾脏ＴｘＡ２合成增加，尿ＴｘＢ２测定可反映肾脏ＴｘＡ２的代谢变化，血浆ＴｘＢ２测定不能反映肾脏（局部ＴｘＡ２的代谢）变化

Plasma TxB2 and Urinary TxB2 Excretion in Diabetes

Abstract The plasma TxB2,urinary albumin,and urinary TxB2 were determined by RIA in 60 diabetics and 23 normal controls.31% (19/60) diabetics had microalburninuria.The urinary TxB2 excretion was significantly higher in patients with microalbuminuria,than those in either the patients with Normoalbuminuria or normal controls(P<0.05).there was no significant differense of plasma TxB2 in the three groups.the results showed that only urinary TxB2 indicate acceleration of renal synthese of TxA2 which may cause the increase of AER.