丝裂霉素C联合自体角膜缘干细胞治疗复发性翼状胬肉的疗效分析

目的:探讨丝裂霉素C联合自体角膜缘干细胞移植治疗复发性翼状胬肉的疗效。方法:将69例87眼复发性翼状胬肉随机分成两组,治疗组:35例45眼行翼状胬肉切除后联合丝裂霉素C及自体角膜缘干细胞移植。对照组:34例42眼行翼状胬肉切除后联合自体角膜缘干细胞移植。结果:术后随访观察了3～12mo。治疗组治愈44眼,治愈率98%,复发1眼,复发率2%;对照组治愈36眼,治愈率86%,复发6眼,复发率14%,两组复发率有统计学意义(χ2=4.273,P=0.039)。结论:丝裂霉素C联合自体角膜缘干细胞移植明显提高治愈率,降低复发率,临床中值得推广。

Analysis of the effect on mitomycin C combined with autologous limbal stem cell in treatment of recurrent pterygium

AIM:To explore the outcome of mitomycin C combined with autologous limbal stem cell transplantation for treatment of recurrent pterygium. ·METHODS:Totally 69 cases 87 eyes with recurrent pterygium were randomly divided into two groups. The treatment group:35 cases 45 eyes after pterygium exci-sion were treated with mitomycin C combined with autologous limbal stem cell transplantation. The control group:34 cases 42 eyes after pterygium excision were treated with autologous limbal stem cell transplantation. ·RESULTS:During a follow-up of 3 to 12 months,in the treatment group 44 eyes were cured and the cure rate was 98%; with 1 eye of recurrence,the recurrence rate was 2%; in the control group,36 eyes were cured and the cure rate was 86%; with 6 eyes of recurrence,the recurrence rate was 14%. Recurrence rate of the two groups was statisti-cally significant (χ2 = 4.273,P=0.039). ·CONCLUSION:Mitomycin C combined with autologous limbal stem cell transplantation significantly increases the cure rate and reduces the recurrent rate,worthy of promotion in clinical therapy.