| 肿瘤坏死因子 α、白介素 6和红细胞生成素与小儿慢性病贫血的相关性分析 |
| |
| 引用本文： | 林雪峰,王忠,吴秀梅,王晓岚,朱小虎.肿瘤坏死因子 α、白介素 6和红细胞生成素与小儿慢性病贫血的相关性分析[J].中国实用妇科与产科杂志,2006,21(2):112-113. |
| |
| 作者姓名： | 林雪峰 王忠 吴秀梅 王晓岚 朱小虎 |
| |
| 作者单位： | 1.常州市儿童医院，江苏常州 213003；2.常州市第二人民医院，江苏常州 213003 |
| |
| 摘 要： | 目的探讨小儿慢性病贫血(ACD)时外周血肿瘤坏死因子(TNF) α、白介素(IL) 6与红细胞生成素(EPO)的变化及其在发病机制中的作用。
方法2002年4月至2004年12月常州市儿童医院收治ACD患儿19例(ACD组)，采用放射免疫分析方法测定患儿外周血清中TNF α、IL 6、EPO水平；对照组为17例上呼吸道感染恢复期患儿。
结果与对照组比较，ACD组患儿血清中TNF α、IL 6均显著增高(P<0.05)。血清TNF α、IL 6与血清铁蛋白质量浓度呈正相关。
结论免疫及炎症反应所产生的细胞因子TNF α、IL 6可能通过干扰铁代谢和抑制EPO生成、钝化对EPO的反应等途径介导了ACD的发生和发展过程。
|
| 关 键 词： | 慢性病贫血 肿瘤坏死因子 α 白细胞介素 6 红细胞生成素 |
| 收稿时间： | 2005-08-09 |
| 修稿时间： | 2005-11-08 |
Exploration on the association between cytokines TNF α、IL 6 、EPO and anemia of chronic diseases in children. |
| |
| Lin Xuefeng,Wang Zhong,Wu Xiumei,et al..Exploration on the association between cytokines TNF α、IL 6 、EPO and anemia of chronic diseases in children.[J].Chinese Journal of Practical Gynecology and Obstetrics,2006,21(2):112-113. |
| |
| Authors: | Lin Xuefeng Wang Zhong Wu Xiumei |
| |
| Institution: | Changzhou Children’s Hospital of Jiangsu Province,Changzhou 213003,China |
| |
| Abstract: | AbstractObjectiveTo explore the role of TNF α，IL 6 and EPO in the pathogensis of anemia of chronic diseases (ACD) in children.
MethodsThe levels of serum TNF α，IL 6 and EPO were determined by immunoassays in 19 ACD patients.
ResultsThe serum levels of TNF α，IL 6 in ACD patients were significantly higher than those in the control group (P<0.05).There were a positive correlation between the serum levels of TNF α or IL 6 and serum ferritin.
ConclusionTNF α，IL 6 resulting from immune and inflammatory reaction may play an important role in the development of ACD by intervening iron metabolism,inhibiting the generation of erythropoietin (EPO)and dulling the response of bone marrow to EPO. |
| |
| Keywords: | Tumor necrosis factor α Interleukin 6 Erythropoietin |
|
| 点击此处可从《中国实用妇科与产科杂志》浏览原始摘要信息 |
| 点击此处可从《中国实用妇科与产科杂志》下载免费的PDF全文 |
