Oxidation-induced aggregation of LDL increases their uptake by smooth muscle cells from human aorta |
| |
| Authors: | O. M. Panasenko A. A. Mel’nichenko D. V. Aksenov V. V. Tertov V. V. Kaplun I. A. Sobenin A. N. Orekhov |
| |
| Affiliation: | (1) Laboratory for Physicochemical Methods of Study and Analysis Institute of Physicochemical Medicine, Russian Ministry of Health, Russia;(2) Laboratory for Mechanisms of Atherogenesis, Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex, Russian Ministry of Health, Russia;(3) Laboratory of Intercellular Interactions, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Russia;(4) Institute of Atherosclerosis, Russian Academy of Natural Sciences, Moscow |
| |
| Abstract: | Oxidative modification of human blood LDL induced by Cu2+, NaOCl, or 2,2-azobis-(2-aminopropane hydrochloride) was followed by their partial aggregation. Separation of oxidized LDL into aggregates and nonaggregated particles showed that they are characterized by a similar degree of oxidative modification. In contrast to nonaggregated particles, LDL aggregates in the same concentration significantly increased cholesterol content in smooth muscle cells from the intact (no involoved in atherosclerosis) human aortic intima. Our results indicate that atherogenicity of LDL oxidized by various factors is mainly associated with the formation of aggregates, but does not depend on the degree of oxidative modification. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 2, pp. 159–162, February, 2007 |
| |
| Keywords: | low-density lipoproteins lipid peroxidation lipoprotein aggregation intracellular cholesterol accumulation atherosclerosis |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
