6-氯代苯骈吡喃类化合物的合成

钾离子通道启开剂大多为苯骈吡喃类化合物。它们具有明显的舒血管活性且很可能成为有前途的抗高血压药物。笔者对发现较早的钾离子通道启开剂cromakalim进行结构修饰的研究时，根据苯骈吡喃类化合物的构效关系，以cromakalim为先导化舍物，设计并合成了4个苯骈吡喃类衍生物，以期望获得抗高血压活性更强，副作用更小的化合物，经元素分析（IR，HNMR，MS）确证其中2个化舍物均未见文献报道。

Synthesis of Some Benzopyran Derivatives

Most of potassium channel openers are benzopyran compounds with significant activity of vasodilatation and may be most likely to become promising antihypertensives drugs. During the study on structural modification of cromakalim as the prototype potassium channel opener, auording to its structure activity relationship, four benzopyran derivatives were designed and prepared in attempt to search for novel antihypertensivse drugs with high efficacy and low toxicity. The structurs of two compounds were not reported previously in the literature, and may be determined by elemental analysis, IR, HNMR and MS.