| 姜黄素β-环糊精包合物的制备工艺研究 |
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| 引用本文： | 韩刚,许建华,李魏娜,宁春玲. 姜黄素β-环糊精包合物的制备工艺研究[J]. 中药材, 2004, 27(12): 946-948 |
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| 作者姓名： | 韩刚 许建华 李魏娜 宁春玲 |
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| 作者单位： | 华北煤炭医学院药学系,唐山,063000 |
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| 摘 要： | 目的:制备了姜黄素β-环糊精包合物以增加难溶性药物姜黄素的溶解度和生物利用度.方法:采用正交试验对包合物的制备条件进行了优化.采用荧光光谱法、薄层色谱法、相溶解度法对包合物进行了验证.结果:制备姜黄素β-环糊精包合物的最佳条件为姜黄素与β-环糊精投料摩尔比为1: 1,乙醇浓度为40%,包合温度50℃,反应时间2 h.结论:该工艺制备的姜黄素β-环糊精包合物的溶解度比姜黄素的溶解度增大了10倍,本工艺适用于制备姜黄素β-环糊精包合物.
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| 关 键 词： | 姜黄素 β-环糊精 包合物 正交设计 |
| 修稿时间： | 2004-06-04 |
Study on Preparation of the Inclusion Compound of Curcumin with β-Cyclodextrin |
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| Han Gang,Xu Jianhua,Li Weina,Ning Chunling. Study on Preparation of the Inclusion Compound of Curcumin with β-Cyclodextrin[J]. Journal of Chinese medicinal materials, 2004, 27(12): 946-948 |
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| Authors: | Han Gang Xu Jianhua Li Weina Ning Chunling |
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| Affiliation: | Pharmaceutical Department, North China Coal Mine Medical College, Tangshan. |
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| Abstract: | OBJECTIVE: The inclusion compound of curcumin with, beta-CD was preparated to increase the solubility and bioavaliability of curcumin. METHODS: Prepare inclusion compound was studied with orthogonal design. The inclusion compound was verified with fluorometry, TLC, and phase solubility. RESULT: The best way to prepare inclusion compound are as follows: the molar ratio between curcumin and, beta-CD is 1:1, temperture is 40 degrees C, reaction time is 2 h. CONCLUSION: Solubility of inclusion compound is 10 times than curcumin. |
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