卡维地洛对慢性心力衰竭左室重塑及心功能的影响

目的探讨卡维地洛对慢性心力衰竭左室重塑及心功能的影响。方法将68例慢性心衰患者,随机分为两组,常规抗心衰药物治疗者为对照组,在此基础上加用卡维地洛治疗者为治疗组。卡维地洛从小剂量开始,根据血压、心率逐渐加大剂量,疗程6个月。观察治疗前后的左室射血分数,左室舒张末期内径,左室收缩末期内径及心率变化。结果在常规治疗基础上加用卡维地洛可改善左室重塑及心功能。结论慢性充血性心力衰竭(CHF),是以肾素——血管紧张素系统(RAAS)交感神经系统(SNS)过度激活,心室功能恶化及心室重塑为特征的综合征。大量实验证实,β受体阻滞剂对CHF有治疗作用,可改善临床症状,增加运动耐量,降低病死率。

Carvedilol to Chronic Heart Failure Left Ventride Reconstitution and Heart Function of Influence

Objective To investigate carvedilol to chronic heart failure left ventrdilol reconstitution and heart function of influence. Methods 68 case chronic heart failure patient divided into randomlytwo groups routine therapy group for control group, and addition carvedilol group, and addition carvedilol for thrapy group, and carvediol from samll dose began. on the basis of blood pressure and heart rate adjustment dose, course of treatment 6 mouth, observation prefherapy and post therapy that patient left ventricular ejetion fraction fraction and heart rate to change. Results Therapy group that prethearpy and posttherapy left ventricular ejection fraction heart rate change and so on all manifest to improve, with control group to compare, had significant difference. Conclusion On the routine therapy foundation addition carvedilol could to improve left ventricular reconstitution and heaa function, that therapeutic effect, to be worth basement layer hospital generalization applincation.