Mixed-model segregation analysis of schizophrenia in the lindelius Swedish pedigrees |
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| Authors: | George P. Vogler Irving I. Gottesman Matthew K. McGue D. C. Rao |
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| Affiliation: | (1) Division of Biostatistics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8067, 63110 St. Louis, Missouri;(2) Department of Psychology, University of Virginia, 22903 Charlottesville, Virginia;(3) Department of Psychology, University of Minnesota, 55455 Minneapolis, Minnesota;(4) Departments of Psychiatry and Genetics, Washington University School of Medicine, 63110 St. Louis, Missouri |
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| Abstract: | To test if familial transmission of schizophrenia is consistent with a model of monogenic inheritance with a multifactorial background, a mixed-model segregation analysis was applied to Swedish pedigrees consisting of 270 probands in 263 nuclear families. Results of the best-fitting mixed-model solutions are consistent with multifactorial transmission and no major gene. However, numerical instabilities prevented formal hypothesis testing, so an irrefutable genetic mechanism remains unidentified. Alternative research strategies that exploit recent advances in molecular genetics are discussed.Supported by grants from the John D. and Catherine T. MacArthur Foundation to Washington University, NIH Grant GM 28719, NIMH Grant MH 17104, and the National Alliance for Research on Schizophrenia and Depression. |
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| Keywords: | schizophrenia segregation analysis mixed model pedigrees |
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