药物性肝损害162例临床分析

目的探讨药物性肝损害发生机制及防治措施。方法回顾性分析162例药物性肝损害患者的年龄、损肝药物、临床表现、治疗及转归。结果导致肝损害的药物常见的有利福平（17．3％，28／162）、消渴丸（16．7％，27／162）、非诺贝特（9．9％，16／162）、白癣皮（8．6％，14／162）及环磷酰胺（7．4％，12／162）等；药物性肝病临床表现为纳差、乏力、恶心、呕吐、皮肤黄疸等；治疗后158例治愈，1例好转，3例死亡。结论使用可能损肝的药物时应加强监测，定期复查肝功能。

Clinical analysis of 162 cases with drug-induced liver disease

Objective To explore the control measures of drug induced liver disease.Methods The age,disease drugs,clinical manifestations,treatment and prognosis of 162 cases with drug induced liver disease were analyzed retrospectively.Results Drug induced liver disease incidence in different age groups are slightly more old age group,Lead to liver damage to many types of drugs,a common anti-TB drugs and other lipid-lowering medicine and Chinese herbal medicine and health drugs can not be ignored.Clinical performance of drug-induced liver disease is different,mostly had good prognosis after treatment,a few turn into cirrhosis,a very small number of fulminant hepatic failure or even death.Conclusion Avoid the use of the drug that may injure the liver,liver protection must also drugs should be regularly reviewed liver function.