瘦素与骨关节炎 |
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引用本文: | 李德,;宋卫东. 瘦素与骨关节炎[J]. 国外医学(外科学分册), 2009, 0(1): 63-66 |
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作者姓名: | 李德, 宋卫东 |
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作者单位: | [1]中山大学附属第二医院矫形外科,广州510120; [2]中山大学附属第二医院骨科,广州510120 |
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基金项目: | 广州市科技计划项目(No.2007J1-C0291) |
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摘 要: | 瘦素是一种由肥胖基因编码的一种分泌型蛋白质,分子质量约为16kDa,主要由白色脂肪组织产生。它具有细胞因子和激素的双重功能,起着调节能量代谢、炎症反应、免疫反应、神经内分泌及血管生成的作用等。本文就瘦素在骨关节炎中作用的研究现状及争论作一综述。
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关 键 词: | 瘦素 骨关节炎 软骨细胞 |
Leptin and osteoarthritis |
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Affiliation: | LI De, SONG Wei-Dong( Department of Osteology, Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510120, China) |
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Abstract: | Leptin, the product of the obese gene, is a 16kDa secreted protein produced by white adipocytes. Because of its dual nature as a hormone and cytokine, leptin plays a role in regulating energy metabolism, inflammation, immune response, neuroendocrine and angiogenesis, and so on. The review focuses on the research and controversy of leptin's effect in osteoarthritis. |
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Keywords: | leptin osteoarthritis ehondrocyte |
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