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Muscle atrophy in muscle-specific tyrosine kinase (MuSK)-related myasthenia gravis
Authors:So-Young MoonSang-Soo Lee  Yoon-Ho Hong
Affiliation:a Department of Neurology, Chungbuk National University College of Medicine, Cheongju, Chungbuk, Republic of Korea
b Department of Neurology, Seoul National University College of Medicine, Boramae Hospital, Shindaebang-2-dong 395, Dongjak-gu, Seoul 156-707, Republic of Korea
Abstract:Myasthenia gravis (MG) with muscle-specific tyrosine kinase (MuSK) antibody (MuSK-MG) is often associated with prominent facial and bulbar muscle atrophy. It remains unclear whether the muscle atrophy is a consequence of long-term corticosteroid treatment, or of the disease process per se. Herein, we report a steroid-naive patient with MuSK-MG who presented with severe weakness and marked atrophy of the facial and tongue muscles.
Keywords:Myasthenia gravis   Muscle-specific tyrosine kinase   Muscle atrophy
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