复发性自然流产与抗磷脂血栓综合征相关性探讨

目的 探讨复发性自然流产（RSA）的原因，了解其与抗磷脂血栓综合生(APL-T)关系。方法 采用ELISA法和PTT－LA法对32例复发性流产及20例正常对照进行抗心磷脂抗体（ACA）和狼疮抗凝物（LA）检测。结果 32例RSA患者中17例APA阳性，阳性率（53．1％）明显高于对照，其中LA阳性率为28．1％，亦明显高于对照。8例诊断为抗磷脂血栓综合征。结论 APA中之LA可能是RSA发生的重要原因，对不明原因的复发性自然流产可考虑为抗磷脂血栓综合征。

Investigation on relation between recurrent spontaneous abortion and antiphospholipid thrombosis syndrome

Objective To investigate the causes of recurrent spontaneous abortion(RSA) and to know the relation between RSA and antiphospholipid thrombosis syndrome(APL T). Methods ELISA and PTT LA were used to detect anticardiolipin antibody(ACA) and lupus anticoagulant(LA) in 32 patients with RSA and 20 normal controls(NC). Results There were 17 positive of antiphospholipid antibody(APA) in RSA group. The incidence was significantly higher than that in NC group. The incidence of LA was also significantly higher than that in NC group. 8 patients were diagnosed as APL T. Conclusion LA may be the more important reason of RSA. It should be considered as APL T when RSA is unexplained.