恶性滋养细胞肿瘤中表皮生长因子的表达与胎盘激素含量的关系

 应用免疫组化方法，采用抗表皮生长因子(EGF)、绒毛膜促性腺激素(hCG)、胎盘泌乳素(hPL)及妊娠特异性β₁糖蛋白(SP₁)抗体，分别检测91例恶性滋养细胞肿瘤(侵蚀性葡萄胎29例，绒毛膜癌29例，转移性侵蚀性葡萄胎12例，转移性绒毛膜癌21例)中EGF和三种胎盘激素的含量。结果表明，不同肿瘤性滋养细胞中EGF的表达以合体滋养细胞(ST)最强，中间型滋养细胞(IT)居中，细胞滋养细胞(CT)最弱。EGF在侵蚀性葡萄胎中的表达明显高于绒毛膜癌(P<0.1)，而在上述二种恶性滋养细胞肿瘤的原发瘤和转移瘤中的表达无差异性(P>0.1)。EGF表达越强，hPL和SP₁的含量越高。由于EGF在侵蚀性葡萄胎中的表达明显高于绒毛膜癌，所以hPL和SP₁的含量在前者显著高于后者(P<0.01)。根据本文和我们较早的观察，我们认为EGF对恶性滋养细胞肿瘤的分化、增生及胎盘激素的分泌均具有一定促进作用。

A study on relationship between expression or epidermal growth factor (EGF) and contents or placental hormones in malignant trophoblastic neoplasms

The expression of EGF and contents of three placental hormones in 91 malignant trophoblastic neoplasms(including 29 invasive moles, 12 metastatic invasive moles,29 choriocarcinomas,21 metastatic choriocarcinomas)were studied immunohistcohemically using a panel of antibodies against EGF,hCG,hPL and SP1.The results indicatsd that the expression of EGF was most intensive in neoplasticsyncytiotrophoblast(ST),middle in neoplastic intermediate trophoblast(IT),most faint in neoplastic cytotrophoblast(CT),There was a relationship between expresson of EGF and secretion of placental hormones in malignant trophoblastic tumors.The expression of EGF was more intensive, the secretion of hPL and SP1 were more marked.Because expression of EGF in invasive mole was more intensive than one in cboriocarcinoma(P<0.1),so contents of hPL and SP1 in the former were more high than one in the latter(P<0.01).According to our present and earlier studies, we consideredthat EGF played a promotive role for differentiation, proliferation and secretion of placental hormonesin malignant trophoblastic neoplasms. Finally, some question abaut expression of EGF and secretionof hCG was discussed.