羧乙基锗倍半氧化物对实验诱发小鼠前胃癌变率的影响

 用羧乙基锗倍半氧化物（Ge-132）处理NSEE诱发的小鼠前胃鳞状上皮增生、癌变，结果发现实验组的癌变率显着低于对照组（P<0.05）,抑癌率为42.9%,实验组核仁组成区相关嗜银蛋白（Ag-NOR）数目及不规则型颗粒的比例显着低子对照组（P<0.05）,而实验组之癌周淋巴细胞浸润反应程度较对照组显着增强（P<0,05）.以上结果表明Ge-132可显着降低NSEE诱发小鼠前胃癌的癌变率，并可影响Ag-NOR在小鼠前胃鳞状上皮细胞中的表达，Ge-132的以上作用可能与其提高小鼠局部细胞免疫力有关。

Effect of carboxyethylgermanium sesquloxide on occurrence or carcinoma in mouse forestomach induced by N-Nitrososarcosine ethylester

In this study, cancer in mouse forestomach was induced by N-nitrososarcosine ethylester(NSEE),and effect of carboxyethylgermanium sesquioxide(Ge-132)on the carcinogenesis of squamous call carcinoma in mouse forestomach was investigated. consults showed that: (1)the occurrenceof cancer in inthervening group was much lower than that in control group,(P<0.05),the inhibitory rate reached 42.9%;(2)the intervening group contained less argyrophilic nucleolar organizer regiong(Ag-NOR)than that of control group (P<0.05),and tiny,irregular Ag-NOR were morefrequently seen in control group (P<0.05);(3)lymphocyte infiltrating response in intervening groupwas more obvious than that in control group (P<0.05).The results suggested that Ge-132 had inhibitory effect on the occurrence of cancer in mouse forestomach; Ag-NOR stains showed that compared with control group,the metabolic level and preliferative sctivity in intervening group wasmuch lower, indicating that Ge-132 could block thd carcinogenesis of cancer in mouse forestomach,and, Ge-132 could increase the immunity of mice in intervening group, and this might be one of themachanisms of antitumor activity of Ge-132.