血清糖链抗原50对胃癌的诊断价值

观察５４例正常人，６２例胃癌及３２例胃良性疾病病人血清糖链抗原５０（ＣＡ５０）含量。结果表明：胃癌病人血清ＣＡ５０含量显著高于正常人和胃良性疾病病人（Ｐ均＜０．００１）；且胃癌早期即有明显增高，晚期增高更为显著。行根治术后其血清含量较术前显著降低而接近正常（Ｐ＜０．０１）；术后复发者又再增高，行姑息术或化疗后较治疗前略降低。若以血清ＣＡ５０９ｋＵ／Ｌ为阳性诊断界值，对胃癌诊断的敏感性为８２．３％，特异性为９３．８％，阳性预计值为９２．７％，胃良性疾病的假阳性率为６．３％，正常人假阳性率为３．７％。癌性腹水病人血清和腹水ＣＡ５０含量均显著高于良性腹水病人（Ｐ均＜０．００１）。提示血清和腹水ＣＡ５０含量检测在胃癌和癌性腹水的诊断，尤其是胃癌的早期诊断和治疗后监测中有一定临床实用价值。

Diagnostic valve of serum CA50 measurement in patients with carcinoma of stomach

Serum CA50 antigen in the nomal individuals and carcinoma of the stomach was assayed by radioimmunoassay,CA50,one type of carbohydrate antigen,consisting mainly of sialylated glycolipid(a ganglioside)and sialylated,Can be isolated from the primary or metaslatic tumors.The serum CA50 content was measured in 52 nomal individuals,62 patients with carcinoma of the stomach and 32 pstients with benign disease of the stomach.The normal value was 3.80±2.45ku/L.The test values in cancer patients were significantly higher than those in normals or benign disease patients.Taking the normal mean value plus two times of standard deviation as positive,the positive rate was 82.3% for Carcinomar of stomach.There was only two positive in 52 normals with a false positive rate of 3. 7%. Furthermore, 38 patients,Cured by effective treatment,gave near normal CA50 value,It is shown that this metsod can be used in carcinoma of stomach diagnosis,differential diagnosis and the monitor, prediction of prognosis.