骨膦和153Sm－EDTMP治疗骨转移癌

 本文报道应用骨膦和/或¹⁵³Sm-EDTMP内照射治疗骨转移癌74例。骨膦组21例,¹⁵³Sm-EDTMP组26例,对骨痛止痛有效率分别为85.7%和80.8%,对骨病变有效率分别为9.5%和19.2%.而联合应用骨膦和¹⁵³Sm-EDTMP治疗31例,止痛有效率和骨病变有效率分别为93.5%和45.2%,后者与前2组相比有显着差异（P<0.05）.三组毒副反应均少见。由此提示,骨膦+¹⁵³Sm-EDTMP疗效显着,安全可靠,可能是当今治疗多发性骨转移癌的优选疗法。

Bonefos and 153Sm-EDTMP in the treatment of metastatic bone cancer

This paper dealt with the treatment of 74 cases of metastatic bone cancer with Bonefos and /or ¹⁵³Sm-EDTMP intraradiation. 21 cases treated with Bonefos and 26 cases treated with ¹⁵³Sm-EDTMP.the total remission rates of the bone pain were respectively 85. 7% and 80. 8% ,and the to-tal effective rates of the bone lesion were respectively 9. 5% and 19. 2 % . 31 cases treated with the combination 13onefos with ¹⁵³Sm-EDTh1P, the two rates before mentioned were respectively 93. 5 % and 45. 2% which was signi-ficantly better than the above results (Ｐ＜0. 05). The side effects were ruse. These results showed that Bonefos plus ¹⁵³Sm-EDTWP are the effective and safe therapy,may be the better treatment of choice against metastaitc multiple bone carcinoma.