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纤溶酶原激活物抑制剂-1与糖尿病足发病关系的研究
引用本文:吕高友,张沈洁,郭凤红,李曦光. 纤溶酶原激活物抑制剂-1与糖尿病足发病关系的研究[J]. 蚌埠医学院学报, 2011, 36(6): 577-578,581
作者姓名:吕高友  张沈洁  郭凤红  李曦光
作者单位:蚌埠医学院第二附属医院内分泌科, 安徽蚌埠 233040
摘    要:目的: 探讨纤溶酶原激活物抑制剂-1(PAI-1)与糖尿病足(DF)发病的关系,为DF的防治提供依据。方法: 42例DF患者为DF组,38例糖尿病(DM)无DF患者为DMNDF组,45名体检健康者为对照组,比较3组间PAI-1、糖基化血红蛋白(HbA1c)、C反应蛋白(CRP)等指标水平的变化。结果: 对照组、DMNDF组、DF组PAI-1、HbA1c、CRP依次升高,且差异均有统计学意义(P < 0.05~P < 0.01)。结论: DF患者PAI-1水平较高;对2型DM患者进行积极干预治疗,降低PAI-1水平,提高纤溶活性,可能延缓动脉硬化、狭窄,减少DF的发生。

关 键 词:糖尿病  2型   糖尿病足   纤溶酶原激活物抑制剂-1
收稿时间:2010-08-03

Relationship between plasminogen activator inhibitor-1 and diabetic foot
L Gao-you,ZHANG Shen-jie,GUO Feng-hong,LI Xi-guang. Relationship between plasminogen activator inhibitor-1 and diabetic foot[J]. Journal of Bengbu Medical College, 2011, 36(6): 577-578,581
Authors:L Gao-you  ZHANG Shen-jie  GUO Feng-hong  LI Xi-guang
Affiliation:Department of Endocrinology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040, China
Abstract:Objective:To investigate the correlation between plasminogen activator inhibitor-1(PAI-1)and diabetic foot,and to provide references for the prevention and treatment of diabetic foot(DF).Methods:Forty-two patients with DF were included in the DF group,38 diabetes mellitus(DM) with non-DF were DMNDF group,and 45 volunteers were selected as control.The plasma concentration of PAI-1,glycosylated hemoglobin(HbA1c)and C reactive protein(CRP) were compared among the groups.Results:There were statistically signifi...
Keywords:diabetes mellitus  type 2  diabetic foot  plasminogen activator inhibitor-1  
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