| 纤溶酶原激活物抑制剂-1与糖尿病足发病关系的研究 |
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| 引用本文： | 吕高友,张沈洁,郭凤红,李曦光.纤溶酶原激活物抑制剂-1与糖尿病足发病关系的研究[J].蚌埠医学院学报,2011,36(6):577-578,581. |
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| 作者姓名： | 吕高友 张沈洁 郭凤红 李曦光 |
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| 作者单位： | 蚌埠医学院第二附属医院内分泌科, 安徽蚌埠 233040 |
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| 摘 要： | 目的: 探讨纤溶酶原激活物抑制剂-1(PAI-1)与糖尿病足(DF)发病的关系,为DF的防治提供依据。方法: 42例DF患者为DF组,38例糖尿病(DM)无DF患者为DMNDF组,45名体检健康者为对照组,比较3组间PAI-1、糖基化血红蛋白(HbA1c)、C反应蛋白(CRP)等指标水平的变化。结果: 对照组、DMNDF组、DF组PAI-1、HbA1c、CRP依次升高,且差异均有统计学意义(P < 0.05~P < 0.01)。结论: DF患者PAI-1水平较高;对2型DM患者进行积极干预治疗,降低PAI-1水平,提高纤溶活性,可能延缓动脉硬化、狭窄,减少DF的发生。
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| 关 键 词： | 糖尿病 2型 糖尿病足 纤溶酶原激活物抑制剂-1 |
| 收稿时间： | 2010-08-03 |
Relationship between plasminogen activator inhibitor-1 and diabetic foot |
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| L Gao-you,ZHANG Shen-jie,GUO Feng-hong,LI Xi-guang.Relationship between plasminogen activator inhibitor-1 and diabetic foot[J].Journal of Bengbu Medical College,2011,36(6):577-578,581. |
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| Authors: | L Gao-you ZHANG Shen-jie GUO Feng-hong LI Xi-guang |
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| Institution: | Department of Endocrinology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040, China |
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| Abstract: | Objective:To investigate the correlation between plasminogen activator inhibitor-1(PAI-1)and diabetic foot,and to provide references for the prevention and treatment of diabetic foot(DF).Methods:Forty-two patients with DF were included in the DF group,38 diabetes mellitus(DM) with non-DF were DMNDF group,and 45 volunteers were selected as control.The plasma concentration of PAI-1,glycosylated hemoglobin(HbA1c)and C reactive protein(CRP) were compared among the groups.Results:There were statistically signifi... |
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| Keywords: | diabetes mellitus type 2 diabetic foot plasminogen activator inhibitor-1 |
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