胃癌区域动脉置泵化疗及外周静脉化疗前后T淋巴细胞亚群及免疫球蛋白的变化

目的　观察胃癌根治术后肿瘤区域动脉置泵化疗及外周静脉化疗对患者免疫功能的影响。方法　 83例行胃癌根治术患者术后 2周开始化疗 ,按化疗方法不同分为 :外周静脉化疗组 (静化组 ,n =4 2 )、泵内化疗组 (泵化组 ,n =4 1) ,两组均在化疗前及化疗结束后 1～ 4d内抽外周静脉血检查T淋巴细胞亚群及免疫球蛋白含量 ,另设对照组 (n =32 )作相同检查。结果　静化组化疗后的CD3和CD4、CD4 /CD8比值及IgG、IgA、IgM含量均明显低于化疗前 (P<0 .0 5 ,P<0 .0 1) ,并明显低于泵化组化疗后 (但CD4、IgM除外 ) ,P <0 .0 5 ;而泵化组化疗前、后CD3、CD4和CD8、CD4 /CD8比值及IgG、IgA含量比较差异无显著性意义 (P >0 .0 5 )。结论　胃癌根治术后肿瘤区域动脉置泵化疗较外周静脉化疗对机体的免疫功能影响较小。

Comparison of the Change of T-Lymphocyte Subsets and Immunoglobulin in Postoperative Gastric Carcinoma Patients with Regional Intra-Artery Implantation Pump Chemotherapy Versus Peripheral Venous Chemotherapy

Objective To observe the turbulence of regional intra-artery implantation chemotherapy and peripheral venous chemotherapy on immunologic function of patients. Methods Two weeks after radical operation of gastric carcinoma, chemotherapy was performed. Eighty-three patients were divided into two groups, one (42 patients) received peripheral venous chemotherapy (PVC) and the other (41 patients) received regional intra-artery implantation pump chemotherapy (RAIPC). The serum T-lymphocyte subsets and immunoglobulin level before and 1-4 days after the chemotherapy were measured. Results After PVC, proportion of CD3 and CD4, CD4/CD8 and IgG, IgA, IgM concentration in PVC group were significantly decreased compared with those before PVC (P< 0.05, P< 0.01), and it is the same when compared with post-RAIPC patients except for CD4 and IgM (P<0.05). In RAIPC group, there were no significant changes in proportion of CD3, CD4 and CD8, CD4/CD8 and IgG, IgA concentration between pre- and post-RAIPC patients. Conclusion After radical operation of gastric carcinoma, RAIPC affects the immunologic function more moderate than PVC.