内蒙古乌兰察布盟结核分枝杆菌耐药性监测研究

目的　掌握乌兰察布盟初始和获得性耐药水平。方法 采用整群抽样方法,由内蒙统一抽样,乌盟的集宁、凉城、化德为监测点。各监测点连续选 26个新发涂阳肺结核病例,期间的复治涂阳病例同时纳入,并对全部培养阳性菌株进行菌型鉴定及SM、INH、RFP、EMB4种抗结核药物的药敏试验。结果 共入选 107例培养阳性病例,总耐药率为 52.3%,其中初始耐药率 35.9%,获得性耐药率 76.7%。初始耐多药率为 7.8%,获得性耐多药率为 53.5%。结论 本地区耐药率均高于全国水平,特别是获得性耐药率高峰发生在 25～34岁青壮年,应引起高度重视。

Study on drug resistance surveillance of tuberculosis in Wulanchabu Meng of Inner Mongolia

Objective To determin the level of initial and a cquire d drug resistance in Wulanchabu Meng and to evaluate the effect of current TB co ntrol strategies.Methods According to surveillance guidelines, cluster sampling method was applied to select 3 surveillance sites in Inner Mon golia, including Jining, Liangcheng and Huade. In each site, 26 new smear positi ve TB patients and all retreatment smear positive TB patients during the same pe riod were select ed to participate the study. Bacterial type and susceptibility test (proportion method for SM, INH, RFP and EMB) were conducted for all culture positive samples .Results 107 patients with pulmonary TB were enrolled from 3 su rveillance sites. 52.3% of them had drug resistance. The initial drug resis tanc e rate was 35.9% and the acquired drug resistance rate was 76.7%. The initial mu lti drug resistance rate was 7.8% and the acquired multi drug resistance rate was 53.5%.Conclusion Local drug resistance rat e is higher than the average level of the whole country. Acquired drug resistanc e occur much more frequently among people aged from 25 to 34 years old. More att ention should be paid to this situation.