| C-erbB-2、Nm23和MDR1基因在原发性乳腺癌中的表达及与转移和预后的相关性 |
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| 引用本文： | 赵大伟,宋燕,吴新宇,高航.C-erbB-2、Nm23和MDR1基因在原发性乳腺癌中的表达及与转移和预后的相关性[J].吉林大学学报(医学版),2006,32(3):473-475. |
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| 作者姓名： | 赵大伟 宋燕 吴新宇 高航 |
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| 作者单位： | 1. 吉林大学中日联谊医院基本外科，吉林 长春 130033；2. 吉林省肿瘤医院乳腺科，吉林 长春130012；3. 吉林大学公共卫生学院卫生化学教研室，吉林 长春 130021；4. 吉林大学基础医学院病理解剖学教研室，吉林 长 |
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| 摘 要： | 目的：探讨C-erbB-2、Nm23和MDR1在原发性乳腺癌中的表达及其与转移和预后的关系。方法：采用免疫组化法（S-P法）检测49例乳腺癌患者手术切除组织中C-erbB-2、Nm23和MDR1的表达，并分析3种基因之间的相关性及其与转移的关系。结果：49例乳腺癌患者中C-erbB-2、MDR1高表达和Nm23低表达的患者转移发生率高（P<0.05）。MDR1的表达与C-erbB-2的表达有相关性（rs＝1.00，P<0.05），Nm23与C-erbB-2的表达无相关性(rs＝0.80，P>0.05)，MDR1的表达与Nm23的表达无相关性s＝0.80，P＞0.05）。C-erbB-2、MDR1同时阳性的患者及C-erbB-2阳性、Nm23阴性的患者转移发生的几率较高，预后较差。结论：C-erbB-2、Nm23和MDR1与乳腺癌转移有关，多个指标联合检测用来估计患者预后指导意义更佳。
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| 关 键 词： | 基因 ERBB-2 基因 肿瘤抑制 基因 MDR |
| 文章编号： | 1671-587X(2006)03-0473-03 |
| 收稿时间： | 2005-11-14 |
| 修稿时间： | 2005年11月14日 |
Expressions of C-erbB-2, Nm23 and MDR1 in primary breast cancer and their relations with metastasis and prognosis |
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| ZHAO Da-wei,SONG Yan,WU Xin-yu,GAO Hang.Expressions of C-erbB-2, Nm23 and MDR1 in primary breast cancer and their relations with metastasis and prognosis[J].Journal of Jilin University: Med Ed,2006,32(3):473-475. |
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| Authors: | ZHAO Da-wei SONG Yan WU Xin-yu GAO Hang |
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| Institution: | 1. Department of General Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China;2. Department of Mastopathy, Tumor Hospital of Jilin Province,Changchun 130012, China;3. Department of Sanitary Chemistry，School of Public Health，Jilin University, Changchun 130021, China;4. Department of Pathology, School of Basic Medical Sciences,Jilin University, Changchun 130021, China |
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| Abstract: | Objective To investigate the expressions of C-erbB-2,Nm23 and MDR1 in primary breast cancer and their relations with metastasis and prognosis.Methods Immunohistochemical method(S-P method) was used to detect C-erbB-2,Nm23,MDR1 expressions in 49 patients with primary breast cancer.The correlations between the three genes and their relations with metastasis and prognosis were analysed.Results The metastasis rate was higher in patients with high-expressions of C-erbB-2,MDR1 and low-expression of Nm23(P<0.05).The expressions of C-erbB-2 and MDR1 had correlation(r_s=1.00,P<0.05).The expression of C-erbB-2 and Nm23 had no correlation(r_s=0.80,P>0.05).The expression of MDR1 and Nm23 had no correlation(r_s=0.80,P>0.05).The metastasis rate in patients with both C-erbB-2( ) and MDR1( ) was higher than the others.Their prognosis was negative.The metastasis rate in patients with both C-erbB-2( ) and Nm23(-) was higher than the others.Conclusion There are correlation between C-erbB-2,Nm23,MDR1 expressions and metastasis of breast cancer.Multi-predictors are better guide to patients than single predictor. |
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| Keywords: | breast neoplasms genes erbB-2 genes tumor suppressor genes MDR |
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