原发性青光眼患角膜内皮细胞的改变

目的 探讨原发性开角型和闭角型青光眼患者的角膜内皮细胞密度及形态的变化。方法 青光眼患者６８人１２５只眼,与患者年龄相匹配的正常人３２人６３只眼。除外角膜病、眼部炎症、外伤及接受过内眼手术的眼。采用非接触型角膜内皮显微镜观察、测量角膜内皮细胞密度和细胞面积等各项指标,用Ｇｏｌｄｍａｎ压平式眼压计测量眼压;分析比较不同类型青光眼各组角膜内皮细胞各项测量指标的差异。结果 青光眼组角膜内皮细胞密度「（２

Changes of corneal endothelium in patients with primary glaucoma

OBJECTIVE: To study the density and morphology of corneal endothelium in patients with primary glaucoma. METHODS: 125 eyes of 68 patients with glaucoma were compared with 63 eyes of 32 patients without glaucoma in the same age group. Exclusion criteria included history of corneal disease, ocular inflammation, trauma, contact lens wearing and surgery. The following date were recorded: type and duration of glaucoma, glaucoma medications, and intraocular pressure (IOP) measurement. Non-contact specular microscope was performed on the central cornea, endothelial images were analyzed by computer. RESULTS: Corneal endothelium density was significantly lower in patients with glaucoma(2386.81 +/- 289.76)/mm2] than that in controls (2540.78 +/- 195.66)/mm2]. Cell density of primary angle-closure glaucoma(PACG) (2262.65 +/- 338.64)/mm2] was significantly low, especially in acute PACG(1925.16 +/- 403.38)/mm2]. The area of endothelium became bigger than normal. But the endothelium density and morphology of primary open-angle glaucoma(POAG) and non-acute PACG had no changes. No correlation was found between mean recent IOP and endothelium density. CONCLUSIONS: This study suggested that patients with acute PACG might have lower corneal endothelium density and bigger cell area than those without glaucoma in the same age group. The endothelium density and morphology of POAG and non-acute PACG were as similar as those of normal persons.