| 枸杞子提取液对RCS大鼠视网膜色素变性的保护作用 |
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| 引用本文： | 倪同上,刘相和,迟焕芳.枸杞子提取液对RCS大鼠视网膜色素变性的保护作用[J].青岛大学医学院学报,2008,44(5). |
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| 作者姓名： | 倪同上 刘相和 迟焕芳 |
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| 作者单位： | 青岛大学医学院人体解剖学教研室,山东,青岛,266021 |
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| 摘 要： | 目的 观察枸杞子提取液(LBA)对RCS大鼠视网膜色素变性的治疗作用.方法 RCS大鼠24只,随机分为给药组和对照组,各12只.给药组大鼠出生后10 d开始喂食LBA(1 mg/kg), 对照组大鼠喂食等量生理盐水.两组大鼠分别于生后25、35、45 d处死,取出眼球,制备组织切片,苏木精-伊红染色和TUNEL法检测视网膜感光细胞的数量.结果 与对照组比较,给药组大鼠出生25 d时感光细胞数目增多,TUNEL阳性细胞数目减少,差异有统计学意义(t=3.12、3.41,P<0.05).结论 在RCS大鼠视网膜变性的早期应用LBA,可对早期变性的神经元发挥保护作用.
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| 关 键 词： | 视网膜 枸杞子 大鼠 |
THE PROTECTION OF LBA ON THE HEREDITARY RETINAL DYSTROPHY RCS RATS |
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| NI TONG-SHANG,LIU XIANG-HE,CHI HUAN-FANG.THE PROTECTION OF LBA ON THE HEREDITARY RETINAL DYSTROPHY RCS RATS[J].Acta Academiae Medicinae Qingdao Universitatis,2008,44(5). |
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| Authors: | NI TONG-SHANG LIU XIANG-HE CHI HUAN-FANG |
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| Institution: | NI TONG-SHANG,LIU XIANG-HE,CHI HUAN-FANG(Department of Anatomy,Qingdao University Medical College,Qingdao 266021,China) |
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| Abstract: | Objective To observe the therapeutic effect of LBA on the hereditary retinal dystrophy RCS rats. MethodsA total of 24 RCS rats were evenly divided into treatment and control group in random.Starting from 10 postnatal days,LBA1 mg/kg was fed on in the treatment group and saline on the control.Photoreceptor necrosis and apoptosis were assessed by HE staining and TUNEL detection. Results Compared with the control,at 25 postnatal days,the number of photoreceptor was more than that of the control(t=3.12,P<0.05),... |
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| Keywords: | Retina Fructus Lycii Rats |
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