Pharmacokinetics of magnolin in rats |
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Authors: | Nam Jin Kim Won Young Song Sun Dong Yoo Sei-Ryang Oh Hyeong-Kyu Lee Hye Suk Lee |
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Institution: | (1) Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan; |
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Abstract: | This study was first conducted to characterize the intravenous and oral pharmacokinetics of magnolin, a major pharmacologically
active ingredient of Magnolia fargesii, at various doses in rats. Magnolin was administered to rats by intravenous injection (0.5, 1 and 2 mg/kg doses) and oral
administration (1, 2 and 4 mg/kg doses), and serial plasma and urine samples were harvested. Magnolin concentrations were
determined by a validated LC/MS/MS assay. After both intravenous and oral administration, the AUCs were linearly increased as the dose increased. Other pharmacokinetic parameters of magnolin (except the V
ss
after the intravenous administration) were also independent of the doses. The extent of absolute oral bioavailability ranged
from 54.3–76.4% for the oral doses examined. Magnolin was considerably bound to rat plasma proteins and the binding value
was constant (71.3–80.5%) over a concentration ranging from 500 to 10000 ng/mL. The pharmacokinetic parameters of magnolin
were doseindependent after both intravenous and oral administration. When given orally, magnolin was rapidly absorbed. |
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