类风湿关节炎相关性间质性肺疾病的研究进展

类风湿关节炎相关性间质性肺疾病发病率高,是类风湿关节炎患者的主要死因之一.其发病机制尚不明确,病史不清,以慢性咳嗽和缓慢进展的呼吸困难为主要症状,肺功能显示限制性通气功能障碍,影像学改变以磨玻璃样阴影、网格状阴影、蜂窝肺最为常见,支气管肺泡灌洗提示存在肺泡炎,病理类型以普通型间质性肺炎最为多见,激素治疗效果差,预后不佳...

Research progress of rheumatoid arthritis-associated interstitial lung disease

The incidence of rheumatoid arthritis-associated interstitial lung disease is high,it is one of the main causes of death in patients with rheumatoid arthritis. The pathogenesis is not well defined and the natural history is unclear. The main symptoms are chronic cough and slowly progressive dyspnea.Pulmonary function tests show restrictive ventilation dysfunction. The most common image changes are ground-glass opacity, grid-like shadows, and honeycombing. Bronchoalveolar lavage shows the presence of alveolitis. The most common pathological type is usual interstitial pneumonia. The therapeutic efficacy of hormone and prognosis are poor. This article reviews the latest research progress of rheumatoid arthritisassociated interstitial lung disease.