甘露糖结合凝集素基因多态性与壮族人群肺结核易感性的关系研究

目的 分析广西壮族人群甘露糖结合凝集素(MBL)基因外显子1多态性,探讨其与肺结核的易感性关系.方法 采用聚合酶链反应-限制性片段长度多态性分析对100名健康壮族正常人和100例壮族肺结核患者的MBL基因外显子1多态性进行分析,分析两组间突变基因型频率的差异.结果 正常对照组与结核病组MBL突变等位基因(B等位基因)频...

Research on relationship of polymorphism of mannose-binding lectin gene with susceptibility to tuberculosis in Zhuang population

Objective To analyze the polymorphism of exon 1 in mannose-binding lectin (MBL)gene in Zhuang population in Guangxi and to explore its relationship with the susceptibility to tuberculosis. Methods The polymorphism of exon 1 in MBL gene in 100 healthy individuals and 100 patients with tuberculosis was determined by polymerase chain reaction-restriction fragment length polymorphism to analyze the differences of mutant genotype frequency in two groups. Results There was no statistical significance on the frequency of MBL mutant allele (B allele) between healthy control group (33.3 % ) and tuberculosis group (35.1% ). Conclusions Mutation of codon 54 in MBL gene may not be the genetic risk factor of tuberculosis in Zhuang population in Guangxi.