| 长链非编码RNA与肿瘤干细胞 |
| |
| 引用本文： | 肖楠,李占峰,姚建新,潘志尧,姚志峰. 长链非编码RNA与肿瘤干细胞[J]. 协和医学杂志, 2021, 12(3): 373-379. DOI: 10.12290/xhyxzz.20190231 |
| |
| 作者姓名： | 肖楠 李占峰 姚建新 潘志尧 姚志峰 |
| |
| 作者单位： | 1.江苏联合职业技术学院南京卫生分院医学技术系，南京 210038 |
| |
| 摘 要： | 肿瘤包含具有干细胞特性的功能细胞亚群,称为肿瘤干细胞(cancer stem cell,CSC),这些细胞亚群在肿瘤的发生和发展中起重要作用.长链非编码RNA(long non-coding RNA,lncRNA)是CSC亚群的关键调节因子,具有诱导CSC自我更新、迁移、侵袭、耐药和分化的重要能力.本文对近年来lncR...
|
| 关 键 词： | 长链非编码RNA 肿瘤干细胞 自我更新 分化 |
| 收稿时间： | 2019-10-22 |
Long Non-coding RNA and Cancer Stem Cells |
| |
| Affiliation: | 1.Faculty of Medical Technology, Nanjing Health School, Jiangsu United Vocational and Technical College, Nanjing 210038, China2.Faculty of Biochemistry, Basic Medicine College, Zhejiang University, Hangzhou 310058, China3.Department of Radiotherapy, Center for Oncological Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China |
| |
| Abstract: | Tumors contain a functional subpopulation of cells that exhibit characteristics of stem cells. This cell subgroup, named cancer stem cell (CSC), plays important roles in the initiation and progression of cancers. As a key regulator of the CSC subgroup, long non-coding RNA (lncRNA) has the important ability to induce self-renewal, migration, invasion, drug resistance and differentiation of CSC. This review summarizes recent research on the functions and mechanisms of lncRNA in the occurrence, maintenance and regulation of different CSC, with the aim of finding new targets for cancer treatment through lncRNA to selectively eliminate CSC and ultimately improve the prognosis of patients with cancer. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《协和医学杂志》浏览原始摘要信息 |
|
点击此处可从《协和医学杂志》下载全文 |
|
