大豆异黄酮对绝经后妇女骨的影响

目的 从临床角度研究大豆异黄酮对兰州地区绝经后妇女骨的影响。方法 在兰州地区筛选出绝经后妇女60人，随机分为大豆异黄酮组(SIF)和对照组(Control),每人每天服用大豆异黄酮90mg或者同等剂量安慰剂，时间6个月。抽血检测血清碱性磷酸酶和血清钙、磷，超声测定胫骨中段骨密度（BMD）。 结果 血清碱性磷酸酶显著下降（P<0.05），血清钙显著升高（P<0.05），胫骨中段BMD显著升高（P<0.05）。结论 大豆异黄酮可增加绝经后妇女骨密度，减少骨丢失。因而可以预防治疗骨质疏松症。

Effect of soy isoflavone on bone mineral density in postmenopausal women

Objective To investigate the effect of soy isoflavone on bone mineral density in postmenopausal women. Methods Sixty postmenopausal women were selected in Lanzhou and randomly divided into 2 groups: soy isoflavone group (SIF) and control group (Control). All subjects were given 90 mg/d isofalvone or placebo for 6 months. Serum AKP, calcium, and phosphate were detected. Bone mineral density (BMD) of the middle tibia was measured using ultrasound. Results Serum AKP in SIF group decreased significantly (P<0.05), while serum calcium increased significantly (P<0.05). BMD of the middle tibia increased significantly (P<0.05). Conclusion Soy isoflavone can increase BMD and reduce bone loss in postmenopausal women, thus can be used for prevention and treatment of osteoporosis.