雌激素对呼吸道病毒感染的保护作用

雌激素是一种多功能甾体类激素,不仅对女性生殖系统,且对内分泌、心血管、代谢系统等均具有明显作用.雌激素对多种肺部疾病具有潜在治疗价值,雌激素受体信号转导在呼吸道病毒感染过程中,参与机体固有免疫、适应性免疫、组织修复过程.动物实验证实,雌激素可以降低炎性因子水平,抑制炎症反应,降低病毒滴度等,从而提高呼吸道病毒感染小鼠的...

Protective Effect of Estrogen on Infection of Respiratory Virus

Estrogen is a multi-functional steroid hormone, which affects not only the female reproductive system, but also endocrine, cardiovascular, and metabolic systems. Estrogen has a potential therapeutic effect on a variety of lung diseases, and estrogen-receptor signaling plays a key role in the innate immunity, adaptive immunity and tissue repair in the course of infection of respiratory virus. Animal experiments have proved that estrogen therapy can reduce inflammatory factors, inhibit inflammatory response, reduce viral titer and so on, so as to improve the survival rate of mice infected with respiratory virus. In this paper, the protective effect of estrogen on the infection of respiratory virus and related mechanisms were reviewed.