基于随机森林算法构建孤独症谱系障碍儿童辅助诊断模型

目的 利用随机森林算法构建孤独症谱系障碍(autism spectrum disorder,ASD)儿童快速辅助诊断模型,有助于ASD儿童的早期发现、早期诊断,减轻临床诊断及评估压力.方法 采用机器学习中随机森林算法,应用社交反应量表(SRS)及文兰适应行为量表(VABS)对黑龙江省346名ASD儿童和90名健康儿童进...

Auxiliary diagnosis model of children with autism spectrum disorder based on random forest

  Objective  The random forest algorithm was used to construct a rapid screening diagnostic prediction model for children with autism spectrum disorder, to provide the references for early detection, early diagnosis of ASD children, and to reduce the pressure of ASD clinical diagnosis and assessment.  Methods  The random forest algorithm of machine learning was applied to build the auxiliary diagnosis model. Totally 346 ASD children and 90 normal children were evaluated by Social Responsiveness Scale and Vineland Adaptive Behavior Scales. ROC curve, and accuracy was used to evaluate the models.  Results  Among the models, the accuracy of 13 feature factors and 7 feature factors were above 0.9, the sensitivity was up to 0.927, the specificity was up to 0.936 and the AUC was up to 0.979. The accuracy, sensitivity, specificity and AUC of the model were 0.943, 0.959, 0.931 and 0.978 respectively. The fitting and generalization effects of the three models were all satisfactory.  Conclusion  A random forest model based on the SRS Scales and Vineland Adaptive Behavior Scales can be used to diagnose ASD accurately and provide scientific basis for the development of rapid screening and diagnosis tools.