内蒙古在校大学生体质量指数与肠道菌群宏基因组浓度的关联

目的 探索内蒙古地区在校大学生体质量指数(BMI)与肠道菌群的关联性,为揭示肠道菌群与肥胖之间的关联性提供参考依据.方法 以内蒙古医科大学为试点,通过招募方式共收集88名志愿者.测量研究对象的身高和体重,并收集粪便样本.提取干粪便样本中的细菌宏基因组,并检测干粪便细菌宏基因组质量浓度(μg/μL).统计分析BMI与肠道...

Correlation between BMI and metagenomics concentration of gut microbiota of college students in Inner Mongolia

  Objective  To explore the correlation between BMI and gut microbiota of college students in Inner Mongolia, and to provide a reference basis for revealing the relationship between intestinal flora and obesity.  Methods  Totally 88 college students from Inner Mongolia Medical University were enrolled, Height and weight were measured, and the feces samples were collected. The bacterial metagenome was extracted from dry feces samples for the concentration detection in per gram of dry feces, expressed as μg/μL. Correlation between BMI and metagenomics concentration of gut microbiota was statistically analyzed. Meanwhile, the metagenomics concentration of gut microbiota in different BMI groups was compared with each other.  Results  There was a negative correlation between BMI and the metagenomics concentration of gut microbiota(r=-0.27, P < 0.05). Significant difference in the concentration of gut microflora was observed between the normal group and the obesity group, the normal group and the overweight/obesity group(F=3.62, P < 0.05). Among the female volunteers, there were significant differences between normal group and overweight group, between normal group and obesity group(F=1.87, P < 0.05). No significant differences in metagenomics concentration of gut microbiota were found in different BMI groups(F=0.60, P>0.05)  Conclusion  There is a correlation between BMI and gut microbiota of college students in Inner Mongolia, the concentration of gut microflora metagenome in overweight and obese people decreased significantly.