| 基质金属蛋白酶抑制剂与胃癌新生血管形成的相关性研究 |
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| 引用本文： | 吕龙,周晓庆,魏谨.基质金属蛋白酶抑制剂与胃癌新生血管形成的相关性研究[J].中国误诊学杂志,2009,9(4). |
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| 作者姓名： | 吕龙 周晓庆 魏谨 |
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| 作者单位： | 1. 江苏省高淳县人民医院普外科,211300
2. 江苏省高淳县人民医院病理科,211300 |
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| 摘 要： | 目的:探讨TIMP-1、TIMP-2表达与胃癌新生血管形成的关系。方法:采用免疫组化方法分析83例胃癌石蜡标本中TIMP-1、TIMP-2的表达及新生血管密度(MVD),并应用图象分析的方法定量分析TIMP-1、TIMP-2在肿瘤中的表达及与MVD之间的关系。结果:无血管转移组MVD低于有血管转移组(P<0.05);低MVD组癌组织TIMP-2 MOD高于高MVD组,而TIMP-1则无显著性。结论:胃癌组织TIMP-2表达能抑制血管形成有关,而TIMP-1则无相关性。
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| 关 键 词： | 金属蛋白酶类组织抑制剂/代谢 胃肿瘤/代谢/病理学 新生血管化 病理性 人类 |
Study on Relationship of NMPI and Angiogenesis in Gastric Cancer |
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| LV Long,ZHOU Xiao-qing,WEI Jin.Study on Relationship of NMPI and Angiogenesis in Gastric Cancer[J].Chinese Journal of Misdiagnostics,2009,9(4). |
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| Authors: | LV Long ZHOU Xiao-qing WEI Jin |
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| Institution: | LV Long; ZHOU Xiao-qing; WEI Jin (Department of Surgery; The People′s Hospital of Gaochun County; Gaochun 211300; Jiangsu; China); |
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| Abstract: | Objective:To evaluate the relation between the expression of TIMP-1,TIMP-2 and angiogenesis in gastric cancer.Methods:The expressions of TIMP-1 and TIMP-2 were quantitatively analyzed respectively with a computer-assisted of digitized microscopic images.Furthermore the relationship between the expression of TIMP-1,TIMP-2 and MVD was analyzed.Results:The MVD was significantly higher in positive vessel metastasis group than in the negative group(P<0.05),meanwhile the meanoptical density(MOD) lf TIMP-2 of c... |
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| Keywords: | Tissue Inhibitor of Metalloproteinases/metabolism Stomach Neoplasms/metabolism/pathology Neovascularization Pathologic Humans |
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