头孢吡肟与头孢他啶治疗细菌性感染的药物经济学评价

目的：比较头孢吡肟与头孢他啶治疗细胞性感染的经济效益和安全性，方法：选择120例细菌性感染病人，进行随机对照治疗观察，头孢吡肟组，头孢他啶组各60例，给药方案为：治疗尿道感头孢吡肟每次1g，2次／d，头孢他啶每次1g，3次／d；其他感染头孢吡肟每次2g,2次／d，头孢他啶每次2g,3次／d；静脉滴注，疗程均为7－14d。采用药物经济学中的成本－效果分析方法。结果：头孢吡肟，头孢他啶治疗细菌性感染有效率分别为91．67％，90．00％，痊愈率分别为70．00％，66．67％。两组药物不良反应发生率分别为8．33％，10．00％，3种细菌性感染类型头孢吡肟的成本－效果比均低于头孢他啶，结论：头孢吡肟治疗细菌性感染的经济效果优于头孢他啶。

Pharmacoeconomic evaluation of Cefepime and Ceftazidime to treat bacterial infection

Object: Compare the economic effect and safety of Cefepime and Ceftazidime to treat bacterial infection. Method: 120 cases bacterial infected patients were selected, then treated and observed in random control, Cefepime and Ceftazidime were 60 cases respectively. Administrative scheme: To treat urethra infection, Cefepime 1g every time, 2 times daily, Ceftazidime 1 g every time, 3 times daily; To treat the infections, Cefepime 2g every time. 2 times daily, Ceftazidime 2g every time, 3 times daily; For venous instillation, course of treatment was all 7 - 14d. The method of cost - effectiveness analysis in Pharmacoeconomics was applied. Residt: The effective ratio of Cefepime and Ceftazidime to treat bacterial infection was 91. 67% , 90. 00% respectively, Fully recover ration was 70. 00%, 66. 67% respectively, the incidence of adverse reaction of two drugs was 8. 33%, 10. 00% respectively. The cost - effectiveness ratio of Cefepime to treat three kinds of bacterial infection was lower than that of Ceftazidime. Conclusion: The ecnomical effect of Cefepime to treat bacterial infection excel Ceftazidime.