| 泽泻提取物不同组分对尿草酸钙结石形成的实验研究 |
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| 引用本文： | 曹正国,刘继红,鲁德曼,吴继洲,尹春萍,周四维. 泽泻提取物不同组分对尿草酸钙结石形成的实验研究[J]. 中国中药杂志, 2003, 28(11): 1072-1075 |
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| 作者姓名： | 曹正国 刘继红 鲁德曼 吴继洲 尹春萍 周四维 |
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| 作者单位： | 1. 华中科技大学,同济医学院,附属同济医院,湖北,武汉,430030
2. 华中科技大学,同济医学院,药学院,湖北,武汉,430030 |
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| 基金项目： | 国家自然科学基金资助项目(39970 891 ) |
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| 摘 要： | 目的 :研究泽泻提取物不同组分对尿草酸钙结石形成的影响 ,并确定其抑制尿草酸钙结石形成的有效部位。方法 :通过喂服泽泻提取物不同组分对乙二醇和氯化铵诱导的大白鼠肾草酸钙结石模型进行实验研究。结果 :服用泽泻醋酸乙酯浸膏的醋酸乙酯洗脱液大鼠的血清尿素氮 (BUN) ,肌酐 (Cr) ,肾钙 (Ca2+ )含量 ,24h尿Ca2+ 分泌量 ,肾组织的草酸钙晶体沉积均明显低于成石组 (P<0.05)。结论 :泽泻醋酸乙酯浸膏的醋酸乙酯洗脱液能抑制实验性高草酸尿症大白鼠体内肾草酸钙晶体的形成 ,是泽泻抑制尿草酸钙结石形成的有效部位。
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| 关 键 词： | 尿石 草酸钙 泽泻 大鼠 |
| 文章编号： | 1001-5302(2003)11-01072-04 |
| 收稿时间： | 2002-11-20 |
| 修稿时间： | 2002-11-20 |
An Experimental Study of Effect of Different Extracts of Alisma Orientalis on Urinary Calcium Oxalate Stones Formation in Rats |
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| CAO Zheng-guo ;LIU Ji-hong ;Radman A.M ;WU Ji-zhou ;YI NG Chun-ping ;ZHOU Si-wei. An Experimental Study of Effect of Different Extracts of Alisma Orientalis on Urinary Calcium Oxalate Stones Formation in Rats[J]. China Journal of Chinese Materia Medica, 2003, 28(11): 1072-1075 |
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| Authors: | CAO Zheng-guo LIU Ji-hong Radman A.M WU Ji-zhou YI NG Chun-ping ZHOU Si-wei |
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| Affiliation: | Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. zgcao2002@hotmail.com |
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| Abstract: | Objective: To study the effect of differe n t extracts of Alisma orientalis on urinary calcium oxalate stone formation i n rats and to identify the ef fective constituents. Method:Different extracts were admi nistered through a stom ach tube to rats of different groups with renal calcium oxalate stones induced by ethylene glycol (EG) and ammonium chloride (AC). Result: In the rats administe red with ethyl acetate elution of ethyl acetate extract, blood Cr, BUN,renal ti ssue calcium content,urinary calcium excretion and crystals deposition in renal tissue were significantly lower than those of the stone formation group. Conclu sion: The ethyl acetate elution of ethyl acetate fraction extract of Alisma orientalis can significantly inhibit urinary calcium oxalate stone formation in rats and be the most effective constituent of Alisma orientalis. |
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| Keywords: | urinary calculi calcium oxalate Alism a orientalis rat |
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